Lynch Syndrome Clinical Trials

29 recruitingLast updated: June 17, 2026

There are 29 actively recruiting lynch syndrome clinical trials across 14 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3. Top locations include Boston, Massachusetts, United States, Milan, Lombardy, Italy, Paris, France. Updated daily from ClinicalTrials.gov.


Lynch Syndrome Trials at a Glance

29 actively recruiting trials for lynch syndrome are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Boston, Milan, and Paris. Lead sponsors running lynch syndrome studies include San Raffaele University, Massachusetts General Hospital, and Associazione Italiana per lo Studio del Pancreas.

Browse lynch syndrome trials by phase

Treatments under study

About Lynch Syndrome Clinical Trials

Looking for clinical trials for Lynch Syndrome? There are currently 29 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Lynch Syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Lynch Syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 29 trials

Recruiting
Not Applicable

Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome

Endometrial CancerLynch SyndromeEarly Detection of Cancer+1 more
Jessica D. St. Laurent, MD25 enrolled1 locationNCT07220239
Recruiting
Phase 2

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Colorectal, CancerLynch SyndromeT Cells
M.D. Anderson Cancer Center40 enrolled1 locationNCT05411718
Recruiting

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

Colorectal CarcinomaLynch Syndrome
Mayo Clinic950 enrolled9 locationsNCT05410977
Recruiting

Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland

Hereditary Breast and Ovarian CancerLynch Syndrome
University of Basel700 enrolled9 locationsNCT03124212
Recruiting
Not Applicable

Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer

Breast CancerColon CancerPancreas Cancer+3 more
Gustave Roussy, Cancer Campus, Grand Paris170 enrolled3 locationsNCT07436312
Recruiting

Integrated Cancer Repository for Cancer Research

Breast CancerLiver CancerEsophageal Cancer+47 more
University of Nebraska999,999 enrolled42 locationsNCT02012699
Recruiting

Familial Investigations of Childhood Cancer Predisposition

Pancreatic CancerHereditary Breast and Ovarian CancerHodgkin Lymphoma+43 more
St. Jude Children's Research Hospital1,500 enrolled1 locationNCT03050268
Recruiting

Lynch Syndrome X-Talk of Enteral Mucosa With Immune System

Hereditary Cancer SyndromeHereditary CancerLynch Syndrome+19 more
San Raffaele University300 enrolled5 locationsNCT06708429
Recruiting
Not Applicable

Videocapsule Endoscopy in Lynch Syndrome

Lynch SyndromeSmall-bowel AdenocarcinomaLynch Syndrome I+5 more
San Raffaele University100 enrolled1 locationNCT05704010
Recruiting
Phase 1

First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived Neopeptides for the Prevention of Cancer in of Lynch Syndrome Carriers

Lynch Syndrome
Fundacion Clinic per a la Recerca Biomédica20 enrolled1 locationNCT07163403
Recruiting

Small Bowel Capsule Endoscopy in Lynch Syndrome

CancerLynch SyndromeMMR Mutation+2 more
Assistance Publique - Hôpitaux de Paris400 enrolled1 locationNCT07472686
Recruiting

Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection

Colorectal, CancerColo-rectal CancerColon Neoplasm+16 more
San Raffaele University1,200 enrolled4 locationsNCT07450612
Recruiting
Not Applicable

Identifying and Caring for Individuals With Inherited Cancer Syndrome

Malignant Solid NeoplasmBreast Ductal Carcinoma in SituHematopoietic and Lymphoid System Neoplasm+3 more
OHSU Knight Cancer Institute27,500 enrolled2 locationsNCT04494945
Recruiting
Not Applicable

A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

Lynch SyndromeHealthyInflammatory Bowel Diseases+1 more
Massachusetts General Hospital30 enrolled1 locationNCT07219537
Recruiting

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

Breast CancerOvarian CancerLung Cancer+15 more
University Health Network, Toronto2,500 enrolled1 locationNCT03702309
Recruiting
Not Applicable

Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)

Urothelial CarcinomaLynch Syndrome
Tampere University Hospital200 enrolled2 locationsNCT06218433
Recruiting
Phase 3

The Cancer of the Pancreas Screening-5 CAPS5)Study

Pancreas CancerPeutz-Jeghers Syndrome (PJS)Gene Mutation+2 more
Johns Hopkins University9,000 enrolled9 locationsNCT02000089
Recruiting
Not Applicable

Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire

Endometrial CancerLynch Syndrome
University of British Columbia30 enrolled1 locationNCT07194551
Recruiting
Not Applicable

CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome

Lynch Syndrome
PERROD Guillaume272 enrolled1 locationNCT05963191
Recruiting

Lynch Syndrome Integrative Epidemiology and Genetics

Lynch Syndrome
University of Colorado, Denver5,000 enrolled2 locationsNCT06582914