RecruitingNot ApplicableNCT04099823

MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics

MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics and Association of Intracranial CSF Flow With Brain Function

Sponsor

Mayo Clinic

Enrollment

50 participants

Start Date

Oct 31, 2019

Study Type

INTERVENTIONAL

Conditions

Alzheimer Disease Hydrocephalus

Summary

The Researchers are trying to test a MR imaging method for detection of Cerebral Spinal Fluid (CSF) flow in the brain to help diagnosis and better understand diseases that affect brain function.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses specialized MRI scans to better understand how cerebrospinal fluid (CSF) — the fluid that surrounds and cushions the brain and spinal cord — flows in patients with hydrocephalus (fluid buildup in the brain) and in people with memory or cognitive problems like Alzheimer's disease. It also includes healthy volunteers for comparison. **You may be eligible if...** - You are a healthy adult with no conditions affecting brain function - OR you have been referred by your doctor for evaluation of abnormal CSF flow (such as normal pressure hydrocephalus) - OR you have impaired cognitive function including conditions like Alzheimer's disease **You may NOT be eligible if...** - You have a medical device that is not safe in an MRI scanner - You require sedation to undergo the scan - You may be pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMRI screening form

Participants will be asked to complete a MRI screening form to check for the presence of metallic implants and materials. People with pacemakers, aneurysm clips, and cochlear implants, or metal/foreign objects in their eyes cannot have an MRI and will not be able to participate in the study.

DIAGNOSTIC_TESTUrine pregnancy test

Pre-menopausal females will be asked if they think they may be pregnant. If yes, a urine pregnancy test will be performed.

DIAGNOSTIC_TESTMR brain

You will be asked to lie down on the bed of the MRI scanner. Then a MRI coil/"antenna" will be placed over your head. This will allow us to get clearer pictures of the tissue of interest. The MRI machine makes loud knocking sounds. Because of this you will be asked to wear earplugs. You will receive a "squeeze ball" alarm in case you need urgent help. We will be able to talk with you and hear you during the MRI exam. The entire MRI scan will last about 45-60 minutes. The MR exam will include standard clinical images as well as the CSF flow imaging.