Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis
Boston Children's Hospital
72 participants
Aug 4, 2020
OBSERVATIONAL
Conditions
Summary
In this research study we want to learn more about the character of neutrophils that are present in the blood of children with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in organs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood of children with sepsis so that they can work to develop therapies to prevent these cells from being harmful.
Eligibility
Inclusion Criteria4
- Are < 18 years old
- Meet the definition of sepsis described in the study design section above. Patients will be eligible for enrollment as control patients if they
- Are < 18 years old
- Are scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure.
Exclusion Criteria2
- Congenital cardiac disease
- On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases
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Interventions
patients in the ICU with infection called sepsis
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04103268