Mitochondrial Donation: An 18 Month Outcome Study.

This study is tracking the outcomes of women who undergo Mitochondrial Donation — a pioneering fertility treatment that allows women carrying mitochondrial DNA mutations to have children without passing on devastating mitochondrial diseases. Mitochondrial diseases are serious conditions caused by defects in the energy-producing parts of cells and can cause severe disability or death in children. This 18-month follow-up study is monitoring both the mothers and any resulting children to ensure safety and inform guidelines. You may be eligible if: - You are a woman with a confirmed mitochondrial DNA (mtDNA) mutation - You are considered suitable for Mitochondrial Donation treatment under a licensed HFEA (Human Fertilisation and Embryology Authority) program - You provide informed consent before treatment begins - You are willing to share health information collected during pregnancy, delivery, and until your child's 18th month of life You may NOT be eligible if: - You have declined Mitochondrial Donation as a treatment - You are unwilling or unable to comply with the study schedule and data-sharing requirements Talk to your reproductive medicine specialist or genetic counselor if you carry a mitochondrial DNA mutation and are considering starting a family — Mitochondrial Donation is a licensed option at specific clinics in the UK.