Microstructure Imaging in Stroke Patients
New Clinical Magnetic Resonance Technologies for Capturing Brain Microstructure Alterations in Patients With Minor Stroke or Transient Ischemic Attack
Danish Research Centre for Magnetic Resonance
90 participants
Dec 23, 2019
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to establish a methodological framework based on existing advanced neuroimaging technologies as a new clinical neuroimaging tool for assessment of possible affected brain connections in stroke and TIA patients. Thus, providing new insights into microstructural changes that may underline why those patients experience deficits like fatigue.
Eligibility
Inclusion Criteria9
- Stroke or TIA (ABCD2>4 and/or acute Diffusion-Weighted Image (DWI) lesion).
- Modified Rankin Scale <=2.
- As perceived by the investigator, have the ability to comply with all requirements of the study protocol.
- Have the ability to understand and sign the Informed Consents Form.
- Multidimensional Fatigue Inventory score >= 12 on general fatigue.
- Healthy
- Age- and sex-matched to patient groups.
- As perceived by the investigator, have the ability to comply with all requirements of the study protocol.
- Have the ability to understand and sign the Informed Consents Form.
Exclusion Criteria16
- Pregnancy or lactation; human chorionic gonadotropin (hCG) urine test is offered for women < 55 years.
- Major medical illness (for instance: anemia, diabetes mellitus, thyroid disorders, cardiovascular disease, electrolyte imbalance, etc.)
- Treated with ritalin or modafinil.
- Known uncontrolled severe malignancy.
- Known drug or alcohol addiction.
- Tiredness due to pharmaceutical side effects, as identified by the Investigator.
- Max body weight of 130 kg.
- Persons who do not wish to be informed about abnormal findings as part of the investigations.
- Pregnancy or lactation; urin hCG test is offered for women < 55 years.
- Major medical illness (for instance: anemia, diabetes mellitus, thyroid disorders, cardiovascular disease, electrolyte imbalance, etc.)
- Anamnestic infection (cystitis, influenza, pneumonia, etc) the last 3 weeks.
- Known malignancy.
- Known drug or alcohol addiction.
- Tiredness due to pharmaceutical side effects.
- Max body weight of 130 kg.
- Persons who do not wish to be informed about abnormal findings as part of the investigations.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
1. Medical history and details of the vascular incident will be collected from the patient and the medical journal. (Duration: 1hr) 2. Neuropsychological measures collected using test measures and questionaries (duration approx 45-60 min).
1\. MRI scan session, which includes Structural, Quantitative, Functional and Diffusion MRI sequences. (maximum duration: 90 min).
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04118790