Fatigue Clinical Trials

217 recruitingLast updated: July 17, 2026

There are 217 actively recruiting fatigue clinical trials across 36 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Baltimore, Maryland, United States, Boston, Massachusetts, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Fatigue Trials at a Glance

217 actively recruiting trials for fatigue are listed on ClinicalTrialsFinder across 6 cities in 36 countries. The largest study group is Not Applicable with 103 trials, with the heaviest enrollment activity in Baltimore, Boston, and New York. Lead sponsors running fatigue studies include Johns Hopkins University, M.D. Anderson Cancer Center, and Centre Hospitalier Universitaire de Saint Etienne.

Treatments under study

About Fatigue Clinical Trials

Looking for clinical trials for Fatigue? There are currently 150 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Fatigue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Fatigue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 217 trials

Recruiting

The COMET Study: a Prospective COhort of MEdical residenTs to Assess Professional, Personal and Psychological Trajectories of Residents in General Internal Medicine

InsomniaFatigue SymptomDepression Disorder+3 more
University of Fribourg800 enrolled3 locationsNCT07707453
Recruiting
Not Applicable

Diaphragmatic Breathing Exercises on Sleep Disorders un Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome (PCOS)Sleep DisordersPittsburg Sleep Quality Index+3 more
Adly A Adam54 enrolled1 locationNCT07698925
Recruiting
Early Phase 1

Evaluation of the Feasibility and Safety of ENCER for Cancer Treatment-Related Fatigue in Patients Receiving Chemotherapy or Radiotherapy

Fatigue Related to Cancer Treatment
Beaura for Para Pharmaceutical Products Trading LLC74 enrolled1 locationNCT07707648
Recruiting
Not Applicable

Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study

PainCancerStress+2 more
University of California, Irvine12 enrolled2 locationsNCT07581080
Recruiting

Capturing Key MG-symptoms Using Smartphone Recordings.

FatigueMyasthenia Gravis
Leiden University Medical Center225 enrolled2 locationsNCT06743490
Recruiting
Phase 3

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

FatigueNarcolepsyEDS+1 more
Harmony Biosciences Management, Inc.258 enrolled14 locationsNCT07675135
Recruiting
Not Applicable

Photobiomodulation Effects on Fatigue and Muscle Damage Induced by NMES

FatigueMuscle DamagePhotobiomodulation+2 more
Federal University of Rio Grande do Sul36 enrolled1 locationNCT07602933
Recruiting
Phase 3

Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue

Cancer-related FatigueBrain Tumor, PediatricMethylphenidate
Odense University Hospital50 enrolled4 locationsNCT06905587
Recruiting
Not Applicable

Wearable Sensory Prosthesis to Improve Coordination, Walking, and Physical Activity

Balance DisordersPeripheral Neuropathy With Type 2 DiabetesBalance+3 more
RxFunction Inc.18 enrolled1 locationNCT07554443
Recruiting
Phase 3

Evaluation of NuvastaticTM in Reducing Cancer-Related Fatigue in Stage IV Colon Cancer Patients Undergoing First-Line Chemotherapy

Colon CancerFatigue
Natureceuticals Sdn Bhd180 enrolled6 locationsNCT07669519
Recruiting
Phase 3

Nuvastatic® Phase III Trial for Fatigue in Triple-Negative Breast Cancer

Breast CancerFatigue Related to Cancer Treatment
Natureceuticals Sdn Bhd250 enrolled6 locationsNCT07669467
Recruiting
Not Applicable

Effect of AI-Assisted Respiratory Training on Pain, Fatigue and Respiratory Parameters in Patients After Open Heart Surgery

PainBreathing ExercisesNursing Care+1 more
Kocaeli University111 enrolled1 locationNCT07665593
Recruiting
Phase 3

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Comparative, Phase III Study to Evaluate the Efficacy and Safety of Nuvastatic® 300mg Capsule in Reducing Cancer-Tumor in Patients With Metastatic Colorectal Cancer Receiving Standard Chemotherapy.

Colon CancerFatigue Related to Cancer Treatment
Natureceuticals Sdn Bhd250 enrolled6 locationsNCT07669454
Recruiting
Not Applicable

Photobiomodulation in Chronic Fatigue Syndrome

Quality of LifeChronic Fatigue Syndrome (CFS)
University of Lahore40 enrolled1 locationNCT07546539
Recruiting

"Balance, Gait, and Motion Analysis in Multiple Sclerosis"

PhysiotherapyFatigueMultiple Sclerosis+7 more
University of Patras40 enrolled2 locationsNCT07630311
Recruiting

Cognitive Reserve and Post-Fatigue Recovery in Older Adults

FatigueAgingMental Fatigue+2 more
Uşak University400 enrolled1 locationNCT07667985
Recruiting
Not Applicable

Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome

FatiguePost-Acute COVID-19 Syndrome
University of Maryland, Baltimore56 enrolled1 locationNCT05977179
Recruiting
Phase 2

Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone

Hypogonadism, MaleFatigue Syndrome, Chronic
Seattle Institute for Biomedical and Clinical Research240 enrolled2 locationsNCT04049331
Recruiting
Not Applicable

Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain

Physiological StressHeat ExposureWork Related Stress+4 more
University of Ottawa20 enrolled1 locationNCT07664462
Recruiting
Not Applicable

Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling

Athletic PerformanceMuscle FatigueOxidative Stress+2 more
Université Catholique de Louvain48 enrolled1 locationNCT07659301