Fatigue Clinical Trials

202 recruitingLast updated: June 17, 2026

There are 202 actively recruiting fatigue clinical trials across 33 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Baltimore, Maryland, United States, Boston, Massachusetts, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Fatigue Trials at a Glance

202 actively recruiting trials for fatigue are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Not Applicable with 96 trials, with the heaviest enrollment activity in Baltimore, Boston, and New York. Lead sponsors running fatigue studies include Johns Hopkins University, M.D. Anderson Cancer Center, and Centre Hospitalier Universitaire de Saint Etienne.

Treatments under study

About Fatigue Clinical Trials

Looking for clinical trials for Fatigue? There are currently 146 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Fatigue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Fatigue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 202 trials

Recruiting

Patient-Centered Assessment of Symptoms and Outcomes

Myalgic Encephalomyelitis/Chronic Fatigue SyndromeCancerFatigue+5 more
National Center for Complementary and Integrative Health (NCCIH)692 enrolled1 locationNCT03952624
Recruiting
Not Applicable

Training in Evidence-based Treatments in Psycho-Oncology

PainDepression, AnxietyDistress, Emotional+2 more
Massachusetts General Hospital115 enrolled1 locationNCT05674357
Recruiting

Photobiomodulation for Chronic Pain and Fatigue in Hypermobile Ehlers-Danlos Syndrome (PBM-SEDh-01)

Chronic PainFatigue Syndrome, ChronicEhlers-Danlos Syndrome, Hypermobile
Centre Medical ISM (Integrative Systemic Medicine)25 enrolled1 locationNCT07637084
Recruiting
Not Applicable

Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome

FatiguePost-Acute COVID-19 Syndrome
University of Maryland, Baltimore56 enrolled1 locationNCT05977179
Recruiting
Phase 2

Solriamfetol for the Treatment of Multiple Sclerosis Fatigue

Multiple SclerosisMultiple Sclerosis Fatigue
Johns Hopkins University46 enrolled1 locationNCT06170970
Recruiting
Not Applicable

Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test.

Cardiovascular DiseasesFatigue Syndrome, Chronic
Hôpital Européen Marseille80 enrolled1 locationNCT07491315
Recruiting
Phase 2

Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue

SurvivorshipNeoplasmsFatigue+3 more
University of Maryland, Baltimore96 enrolled1 locationNCT06482515
Recruiting

"Balance, Gait, and Motion Analysis in Multiple Sclerosis"

PhysiotherapyFatigueMultiple Sclerosis+7 more
University of Patras40 enrolled2 locationsNCT07630311
Recruiting
Not Applicable

tAN for First Responders

Mental StressMental Fatigue
Spark Biomedical, Inc.30 enrolled1 locationNCT07109349
Recruiting
Not Applicable

Muscular Fatigue vs. Mental Fatigue on Balance, Proprioception and Reaction Time

Mental FatigueMuscular Fatigue
Istinye University66 enrolled1 locationNCT07620860
Recruiting
Not Applicable

The Effect of Progressive Muscle Relaxation and Deep Breathing Exercises Applied to Palliative Care Cancer Patients on Dyspnea, Fatigue, and Self-Care Behaviors

CancerFatiguePatient+2 more
Ankara University90 enrolled4 locationsNCT07619209
Recruiting
Phase 1

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

Chronic Fatigue SyndromeHealthyMultiple Sclerosis+1 more
University of Alabama at Birmingham120 enrolled1 locationNCT03759522
Recruiting
Not Applicable

Exercise for Oncology Care Professionals

Compassion FatigueBurnout, Caregiver
Melanie Keats70 enrolled2 locationsNCT05884073
Recruiting
Not Applicable

Active Living After Cancer: Implementation Within Be Well Acres Homes

CancerFatigue
M.D. Anderson Cancer Center164 enrolled1 locationNCT06907706
Recruiting
Not Applicable

Exercise Therapy and Cognitive Behavioural Therapy for Fatigue in Female Cancer Patients in Singapore

Breast Cancer FemaleFatigue
National Cancer Centre, Singapore100 enrolled4 locationsNCT07116161
Recruiting

A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS

Chronic Fatigue SyndromeEncephalomyelitis
Mayo Clinic40 enrolled1 locationNCT07551999
Recruiting
Not Applicable

Effect of Hot Spring Therapy on Central Fatigue Elimination During Altitude Training

Cognitive ImpairmentSports PerformanceCentral Fatigue+3 more
Macao Polytechnic University27 enrolled1 locationNCT07615478
Recruiting
Not Applicable

Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period

Muscle FatigueLower Extremity Explosive Power DeficitSports Recovery+1 more
Guangzhou Sport University34 enrolled1 locationNCT07604948
Recruiting

Mechanisms of Persistent Fatigue

Fatigue Post Viral
University Hospital, Akershus300 enrolled1 locationNCT07394855
Recruiting
Early Phase 1

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

Fatigue Syndrome, Chronic
National Institute of Neurological Disorders and Stroke (NINDS)47 enrolled1 locationNCT06472622