Fatigue Clinical Trials

132 recruiting

Fatigue Trials at a Glance

174 actively recruiting trials for fatigue are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Not Applicable with 75 trials, with the heaviest enrollment activity in Baltimore, Boston, and New York. Lead sponsors running fatigue studies include M.D. Anderson Cancer Center, Johns Hopkins University, and Centre Hospitalier Universitaire de Saint Etienne.

Treatments under study

About Fatigue Clinical Trials

Looking for clinical trials for Fatigue? There are currently 132 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Fatigue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Fatigue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 174 trials

Recruiting

Patient-Centered Assessment of Symptoms and Outcomes

Myalgic Encephalomyelitis/Chronic Fatigue SyndromeCancerFatigue+5 more
National Center for Complementary and Integrative Health (NCCIH)692 enrolled1 locationNCT03952624
Recruiting

Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)?

FatigueMultiple SclerosisHypogammaglobulinemia
Insel Gruppe AG, University Hospital Bern106 enrolled1 locationNCT05357781
Recruiting

Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome

Post-Acute COVID-19 Vaccination SyndromePostviral Fatigue
University of Bern200 enrolled1 locationNCT07400848
Recruiting

Explanatory Factors and Predictors of Fatigue in Patients With Sjögren's Disease: A 3-month Longitudinal Study

FatigueSjogren's Disease
Kahramanmaras Sutcu Imam University100 enrolled1 locationNCT07544394
Recruiting
Not Applicable

Virtual Patient Groups for Sarcoidosis Associated Fatigue

DepressionFatigueAnxiety+2 more
The Cleveland Clinic100 enrolled1 locationNCT07073963
Recruiting
Phase 3

Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue

Cancer-related FatigueBrain Tumor, PediatricMethylphenidate
Odense University Hospital50 enrolled4 locationsNCT06905587
Recruiting
Not Applicable

Recovery After Fatigue in Young Athletes: Comparison Between TECAR Therapy and Cycle Ergometer"

Muscle FatigueHealthy Adult
Maimónides Biomedical Research Institute of Córdoba48 enrolled1 locationNCT07547566
Recruiting
Phase 2

Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue.

FatigueStrokeStroke, Chronic
VA Office of Research and Development60 enrolled1 locationNCT05584124
Recruiting
Not Applicable

Mindfulness-Oriented Respiratory Distress Symptom Intervention for Lung Cancer

Symptom ClusterBreathlessnessCoughing+3 more
The Hong Kong Polytechnic University64 enrolled1 locationNCT07281300
Recruiting

Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)ME/CFS Following COVID-19
Charite University, Berlin, Germany50 enrolled1 locationNCT07529197
Recruiting
Not Applicable

Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis

FatigueMultiple Sclerosis
Accelerated Cure Project for Multiple Sclerosis2,000 enrolled6 locationsNCT06441617
Recruiting

The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery

Postoperative Neurocognitive DisorderElderly PatientsCardiac Surgery+4 more
Ziekenhuis Oost-Limburg80 enrolled1 locationNCT07200726
Recruiting
Not Applicable

REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibitors

Ovarian CancerPrimary Peritoneal CancerFallopian Tube Carcinoma+4 more
Dana-Farber Cancer Institute240 enrolled6 locationsNCT06710548
Recruiting
Phase 4

The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study

Postoperative FatiguePostoperative Sleep Disturbances
Ziekenhuis Oost-Limburg102 enrolled1 locationNCT06480539
Recruiting
Not Applicable

tAN for First Responders

Mental StressMental Fatigue
Spark Biomedical, Inc.30 enrolled1 locationNCT07109349
Recruiting
Not Applicable

Decentralized Clinical Trial of Effectiveness of EnergyPoints App in Cancer Survivors

Fatigue in Cancer SurvivorsHealth-related Quality of LifeSleep Disturbances+1 more
5 Point App, Inc.180 enrolled1 locationNCT06754722
Recruiting
Not Applicable

Neuromodulation and Fatigue

FatigueHealthy Aging
University of Oklahoma40 enrolled1 locationNCT05487131
Recruiting
Phase 2

Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency

CancerFatigueHypogonadism, Male
Seattle Institute for Biomedical and Clinical Research230 enrolled3 locationsNCT04301765
Recruiting
Not Applicable

Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test.

Cardiovascular DiseasesFatigue Syndrome, Chronic
Hôpital Européen Marseille80 enrolled1 locationNCT07491315
Recruiting
Not Applicable

Neuromuscular Effects of Acute Fatigue in Adolescent Basketball

GenderFatigue RecoveryBasketball+1 more
Biruni University40 enrolled1 locationNCT07467525