RecruitingNot ApplicableNCT04149496

IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer

A Prospective Series of IVF Cases Utilizing in Vitro Maturation (IVM) With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Embryo Transfer Using a Subsequent Frozen Embryo Transfer Cycle

Sponsor

Bruce Rose, MD

Enrollment

300 participants

Start Date

May 10, 2019

Study Type

INTERVENTIONAL

Conditions

Polycystic Ovary Syndrome

Summary

A protocol was developed to improve pregnancy results after IVM compared to results from studies in the literature. Differences from most published protocols include the use of the Steiner-Tan needle to optimize oocyte environment during oocyte retrieval, use of oral medications and very low doses of FSH, and delayed embryo transfer during subsequent warmed cryo-preserved embryo transfer. Eligible patient have a PCO pattern in their ovaries during transvaginal ultrasound.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 38 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an improved approach to in vitro maturation (IVM) — a fertility treatment where eggs are collected before they fully mature and matured in the lab instead of using heavy hormone injections. This method aims to make IVF safer and more affordable, particularly for women at risk of ovarian hyperstimulation syndrome. **You may be eligible if...** - You have a polycystic ovary (PCO) pattern, meaning more than 25 antral follicles seen on ultrasound - Your AMH (anti-Müllerian hormone) level is above 3.5 (indicating a high egg reserve) **You may NOT be eligible if...** - Your BMI is above 35 - Your body anatomy makes egg retrieval through the vagina difficult or unsafe - You have a medical condition that makes pregnancy or IVF risky Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

COMBINATION_PRODUCTin vitro maturation of oocytes

Immature oocytes (rather than mature oocytes) are harvested as in IVF. These oocytes are allowed to mature in the laboratory before fertilization

Locations(1)

Brown Fertility

Jacksonville, Florida, United States

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NCT04149496

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