RecruitingNCT04160507

Duke APOL1 Research Biorepository

Sponsor

Duke University

Enrollment

200 participants

Start Date

Dec 13, 2019

Study Type

OBSERVATIONAL

Conditions

End-stage Kidney Disease

Summary

The Duke ApoL1 Nephropathy Biorepository aims to address needs within non-diabetic kidney failure research by utilizing existing and, when necessary, developing new infrastructure to support the consent of patients and the collection of dedicated samples for ApoL1 Nephropathy biorepository. The mutations in ApoL1 gene that are strongly associated with kidney disease are only present in individuals of recent African ancestry (i.e., black people). Caucasians do not have these ApoL1 mutations nor the associated kidney disease. Therefore, majority of subjects recruited for this study will be self-identified African Americans, Afro-Caribbean and other black individual. Study subjects will include individuals with end stage kidney disease and those without any clinical evidence of kidney disease. Additionally, healthy black adults with no known history of kidney disease will be recruited as controls in this study because they are the only group that can fill this role.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a research biorepository (a collection of biological samples and health data) studying the APOL1 gene, which is more common in people of African ancestry and is linked to higher rates of kidney disease. The goal is to understand why people with certain APOL1 gene variants are at greater risk for kidney failure and to help find new treatments. **You may be eligible if...** - You self-identify as African American, Afro-Caribbean, or another Black individual - You are either at various stages of kidney disease, OR a healthy adult 50 or older with no known kidney disease (as a control) **You may NOT be eligible if...** - You are a healthy Black adult control with known kidney disease - You are a Black adult with kidney disease caused specifically by diabetes (diabetic nephropathy) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBiorepository

To collect and store biological samples (whole blood and urine), along with relevant medical information, from adult inpatients and outpatients. Buffy coats will also be received from H3Africa Kidney Disease Research Network.