RecruitingPhase 1NCT07426380

A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function

A Phase 1, Multicenter, Parallel-Design, Single Dose, Open-Label Study to Evaluate the Pharmacokinetics and Safety of Eloralintide in Participants With Severe Renal Impairment and End Stage Renal Disease (ESRD) Compared With Participants With Normal Renal Function


Sponsor

Eli Lilly and Company

Enrollment

28 participants

Start Date

Feb 24, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of the study is to assess the amount of Eloralintide (LY3841136) that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment and to healthy participants. The study drug will be administered subcutaneously (SC) (under the skin). For each participant, the study will last about 14 weeks, excluding screening.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a drug called eloralintide (LY3841136) behaves in the body in people with severely reduced kidney function or kidney failure, compared to people with normal kidneys. The goal is to understand if kidney disease affects how the drug is processed, so that appropriate dosing can be established. **You may be eligible if...** - You weigh 55 kg or more and have a BMI between 19.0 and 40.0 kg/m² - You have no history of low blood sugar episodes - For the healthy group: your kidneys function normally (eGFR ≥ 90 mL/min) and your HbA1c is 6.5% or below - For the kidney impairment group: you have severe chronic kidney disease (eGFR < 30 mL/min) or end-stage kidney disease on dialysis **You may NOT be eligible if...** - You have a history of unexplained low blood sugar - Your BMI or weight falls outside the required range - Your kidney function does not match the group requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLY3841136

Administered SC


Locations(2)

Floridian Clinical Research, LLC

Miami Lakes, Florida, United States

Omega Research Orlando LLC

Orlando, Florida, United States

View Full Details on ClinicalTrials.gov

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NCT07426380


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