RecruitingPhase 1NCT04162353

BCMA-CD19 cCAR in Multiple Myeloma and Plasmacytoid Lymphoma

BCMA-CD19 cCAR in Relapsed and /or Refractory Multiple Myeloma and Plasmacytoid Lymphoma


Sponsor

iCell Gene Therapeutics

Enrollment

12 participants

Start Date

Jul 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

This is a phase I, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of BCMA-CD19 cCAR in patients with relapsed and/or refractory multiple myeloma and plasmacytoid lymphoma.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is testing a CAR T-cell therapy called BCMA-CD19 cCAR for patients with multiple myeloma or a related blood cancer called plasmacytoid lymphoma. CAR T-cell therapy takes a patient's immune cells, engineers them in the lab to recognize and attack cancer cells, and infuses them back. This particular therapy targets two proteins — BCMA and CD19 — that appear on cancer cells. **You may be eligible if...** - You have multiple myeloma or plasmacytoid lymphoma - You have exhausted standard treatment options - You have stopped immunosuppressive drugs or steroids for at least 1 week - You are not pregnant - You have signed an informed consent form **You may NOT be eligible if...** - You have had a prior solid organ transplant - A potentially curative treatment (like chemotherapy or stem cell transplant) is still available to you - You have previously received a treatment targeting both BCMA and CD19 together Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALBCMA-CD19 cCAR T cells

BCMA-CD19 cCAR T cells administered to patients, will be either fresh or thawed CAR T cells by IV injection after receiving lymphodepleting chemotherapy


Locations(2)

Peking University Shenzhen Hospital, China

Shenzhen, Guangdong, China

Chengdu Military General Hospital

Chengdu, Sichuan, China

View Full Details on ClinicalTrials.gov

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NCT04162353


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