RecruitingNot ApplicableNCT04166825
Ovarian Hyperstimulation and Fibrin Clot Properties.
The Impact of Different Ovarian Hyperstimulation Protocols on Coagulation and Fibrinolysis.
Sponsor
Jagiellonian University
Enrollment
300 participants
Start Date
Nov 18, 2019
Study Type
INTERVENTIONAL
Conditions
Summary
The impact evaluation of ovarian hyperstimulation on coagulation and fibrinolysis in infertile women. Comparative analysis between different ovarian stimulation protocols on thrombin formation and efficiency of fibrinolysis in women diagnosed with infertility.
Eligibility
Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years
Inclusion Criteria1
- infertility defined based on the WHO 2010 criteria
Exclusion Criteria14
- ovarian involvement
- oral contraceptives use within previous 3 months
- dienogest therapy within 3 months until ART
- thrombotic events in the medical history
- severe hypertension
- diabetes mellitus
- the presence of known VTE risk factors, including obesity, recent major surgery with prolonged immobilization or trauma,
- deficiency of antithrombin, protein C or protein S,
- antiphospholipid syndrome,
- known malignancy,
- any chronic inflammatory diseases (e.g. rheumatoid arthritis)
- advanced chronic renal disease (estimated glomerular filtration rate \[eGFR\] \<30 ml/min),
- international normalized ratio (INR) more than 1.2 at the day of blood draw
- pregnancy.
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Interventions
DIAGNOSTIC_TESTfibrin clot properties
Assessment of thrombin generation and efficiency of fibrinolysis.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04166825
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