The Use of Nanoparticles to Guide the Surgical Treatment of Prostate Cancer

This study is testing whether tiny nanoparticles can help surgeons find and remove the right lymph nodes during prostate cancer surgery. The nanoparticles light up on imaging, making it easier to see which nodes may contain cancer. **You may be eligible if...** - You are 18 or older - You have high-risk prostate cancer (stage T3a or above, Gleason score 8–10, or PSA over 20) - You are scheduled for a radical prostatectomy (surgical removal of the prostate) - OR you have had prior prostate cancer treatment and now have suspicious lymph nodes on imaging (CT, MRI, or PSMA PET scan) and are scheduled for salvage lymph node removal surgery **You may NOT be eligible if...** - You have a metal implant or severe claustrophobia that prevents MRI scanning - You have previously had androgen deprivation therapy or pelvic radiation (for the primary surgery group) - You have serious health problems like kidney insufficiency, recent heart attack, or severe heart disease - You weigh over 400 lbs (due to PET scanner limits) Talk to your doctor to see if this trial is right for you.