RecruitingNCT04170244

Skin Microbial Ecology in Atopic Dermatitis

Longitudinal "Real-World" Changes in Skin Microbial Ecology in Atopic Dermatitis (AD) and Psoriasis (PS) Patients

Sponsor

University of Rochester

Enrollment

240 participants

Start Date

Apr 17, 2019

Study Type

OBSERVATIONAL

Conditions

Healthy Atopic Dermatitis Psoriasis

Summary

Everybody's skin has bacteria that normally lives on it. Previous research has shown that people with eczema (or atopic dermatitis \[AD\]) have much higher concentrations of a certain bacteria (S. aureus), especially when their disease is active but little is known about the role that this bacteria plays in psoriasis (i.e. disease severity, biomarkers and skin barrier function). The overarching purpose of this longitudinal study is to understand how the abundance of skin S. aureus (and several commensal bacteria) change as a consequence of standard of care treatment in the URMC dermatology clinics. Other assays and biospecimens will also be collected to address a number of questions.

Eligibility

Min Age: 13 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying AD subject visit sampling procedures, Healthy control visit sampling procedures, and others for people with atopic dermatitis, healthy, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 13 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERAD subject visit sampling procedures

Skin swabs for microbial analysis, Tape stripping and transepidermal water loss measurements (TEWL) with tape stripping (all patients) to assess skin barrier function, blood serum (adults \& optional for adolescents), and optional biopsy (adults only)

OTHERPS subject visit sampling procedures

Skin swabs for microbial analysis, Tape stripping and transepidermal water loss measurements (TEWL) with tape stripping (all patients) to assess skin barrier function, and blood serum (optional for all PS subjects)

OTHERHealthy control visit sampling procedures

Locations(1)

University of Rochester Medical Center

Rochester, New York, United States

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NCT04170244

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