Psoriasis Clinical Trials

Many trials require a washout period where you stop your current biologic before starting the study drug. The required washout length varies by trial and by which biologic you are currently taking, typically ranging from four to twelve weeks. Some trials, however, are designed specifically for patients who have failed biologics and may have shorter or no washout requirements. Discuss the timing and safety of any washout period with your dermatologist.

Yes. While many trials focus on moderate-to-severe psoriasis, there are studies testing new topical treatments, phototherapy approaches, and combination regimens for mild disease. Trials for scalp psoriasis, nail psoriasis, and genital psoriasis — specific forms that significantly affect quality of life even when overall body surface area is limited — are also available.

Usually, yes. Most trials require you to discontinue systemic treatments and biologics for a defined washout period before enrollment. Topical treatments like moisturizers and low-potency corticosteroids are often permitted during screening. Your dermatologist can help you plan the transition safely and manage any flares that occur during the washout.

The active treatment phase typically lasts 12 to 52 weeks, with many trials offering an open-label extension period where all participants receive the study drug for an additional one to three years. When a trial ends, your study team will help transition you to an appropriate standard treatment. If the trial drug is later approved, you may be among the first patients prescribed it.