RecruitingPhase 4NCT04180397

Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.

Goal Directed Fluid Removal With Furosemide in Intensive Care Patients With Fluid Overload - A Randomised, Blinded, Placebo-controlled Trial (GODIF).

Sponsor

Morten H. Bestle

Enrollment

1,000 participants

Start Date

Aug 17, 2020

Study Type

INTERVENTIONAL

Conditions

Fluid Overload

Summary

This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is excreted.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Furosemide and a drug called Isotonic saline for people with fluid overload. The study is currently recruiting participants at 29 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFurosemide

Furosemide 10 mg/ml for injection/infusion

DRUGIsotonic saline

Isotonic saline used as placebo (injection/infusion)

Locations(29)

Department of Intensive Care, Liverpool Hospital

Sydney, Australia

Department of Intensive Care, Royal North Shore Hospital

Sydney, Australia

Department of Intensive Care, University Hospital of Ostrava

Ostrava, Czechia

Department of Intensive Care, University Hospital of Pilsen

Pilsen, Czechia

Department of Intensive Care, IKEM

Prague, Czechia

Department of Intensive Care, Sygehus Sønderjylland Aabenraa

Aabenraa, Denmark

Departmen of Intensive Care

Aalborg, Denmark

Department of Intensive Care, Aarhus University Hospital

Aarhus, Denmark

Department of Intensive Care, Rigshospitalet

Copenhagen, Denmark

Departement of Intensive Care, Gentofte Hospital

Gentofte Municipality, Denmark

Department of Intensive Care, Herlev Hospital

Herlev, Denmark

Department of Intensive Care, Regionshospital Gødstrup

Herning, Denmark

Department of Intensive Care, Nordsjællands hospital

Hillerød, Denmark

Department of Intensive Care, Regionshospital Nordjylland Hjørring

Hjørring, Denmark

Department of Intensive Care

Kolding, Denmark

Department of Intensive Care, Zealand University hospital

Køge, Denmark

Department of Intensive Care

Odense, Denmark

Department of Intensive Care, Regionshospitalet Randers

Randers, Denmark

Department of Intensive Care, University Hospital Zealand, Roskilde

Roskilde, Denmark

Department of Intensive Care

Vejle, Denmark

Regionshospitalet Viborg

Viborg, Denmark

Department of Intensive Care, Tampere University Hospital

Tampere, Finland

Department of Intensive Care

Turku, Finland

Department of Intensive Care, Landspitali National University Hospital of Iceland

Reykjavik, Iceland

Vilnius University Hospital Santaros Clinics

Vilnius, Lithuania

Department of Critical Care, University Medical Center Groningen

Groningen, Netherlands

Department of Intensive Care, Ålesund Sjukehus

Ålesund, Norway

Department of Intensive Care, Stavanger University Hospital

Stavanger, Norway

Department of Intensive Care, Inselspital

Bern, Switzerland

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NCT04180397

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