RecruitingNCT04185779

COLO-COHORT (Colorectal Cancer Cohort) Study

Sponsor

South Tyneside and Sunderland NHS Foundation Trust

Enrollment

15,000 participants

Start Date

Dec 13, 2019

Study Type

OBSERVATIONAL

Conditions

Colorectal, Cancer Colorectal Adenoma Colorectal Neoplasm Predictive Cancer Model Model

Summary

This is a cross-sectional study aimed at identifying factors which best predicts patients at high risk of colorectal cancer or colorectal adenomas and to develop a risk prediction model.

Eligibility

Min Age: 18 Years

Inclusion Criteria10

Group A
Aged ≥30 years\* and able to give informed consent
Patients attending colonoscopy
Through Bowel Cancer Screening Programme (FIT positive, Bowelscope conversion, surveillance)
Through standard NHS care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, planned polypectomy\*\*, those referred on basis of family history, abnormal cross-sectional imaging, polyp surveillance or post CRC surveillance)
The age of 30 was chosen to ensure that this is a population likely to be enriched for colorectal neoplasia with neoplasia below this age uncommon \*\*In those attending for planned polypectomy, the results from the initial colonoscopy and the endoscopy where the polypectomy is undertaken will be summated for purposes of calculating the neoplasia profile
(COLO-SPEED) Group B
Any patient attending for colonoscopy and able to give informed consent
≥ 18 years old
Patient from the North of England

Exclusion Criteria11

Group A
Unable to give informed consent
Known polyposis syndrome
Previous total colectomy
Known colonic stricture which would limit complete colonoscopy
Attending for planned therapeutic procedure other than polypectomy, such as insertion of colonic stent
Attending for assessment of known inflammatory bowel disease (IBD) activity or for IBD surveillance
Patients currently recruited into an interventional CTIMP for CRC prevention\*
COLO-SPEED (Group B) \*\*
Unable to give informed consent
Not in a centre supported by COLO-SPEED infrastructure (North of England)