RecruitingNCT04194372

Signature of the Risk Profile of Mortality in a Hospital Cohort of Patients With Metabolic Diseases

Sponsor

University Hospital, Lille

Enrollment

10,000 participants

Start Date

Dec 20, 2019

Study Type

OBSERVATIONAL

Conditions

Metabolic Disease

Summary

Epidemiological studies are usually conducted in the general population in adults without complications or pathology at baseline. The results obtained are therefore often better designed for primary prevention use. The prediction of mortality risk in patients with complications and requiring hospital follow-up is less well known. The study purpose is to determine a mortality risk profile in a hospital cohort of patients with pathologies associated with metabolic diseases. Today the "multimaker" scores based on a panel of biomarkers - have significantly improved the discriminating power of prediction models existing in many pathologies. It is no longer a single biomarker that can improve risk prediction but a complete and cross-sectional profile that is sought after. We aim to establish a personalised mortality risk profile by combining clinical and biological parameters including metabolomics, genetics, transcriptomics and epigenomics by high throughput screening of biological samples.

Eligibility

Min Age: 18 Years

Inclusion Criteria28

Diabetic: antecedent - treatment - or glycemia> = 1.26 g / dl - or HbA1C> = 6.5% and or
Obese: BMI> = 30 and or
Metabolic syndrome defined AND
Patient having given written consent to participate in the study or collection of the consent of the witness
Social insured patient (excluding AME)
Patient willing to comply with all procedures of the study and its duration AND
Patient also presenting a pathology among:
Cardiology:
Coronary patient(history of myocardial infarction, coronary bypass, or coronary angioplasty or stenosis greater than 50% on an epicardial vessel documented on coronary angiography)
Patient with systolic or diastolic heart failure
Patient with atrial fibrillation
Patient with aortic stenosis (Vmax> 2.5 m / s)
Patient with high blood pressure
neurology:
ischemic stroke
intracerebral hemorrhage
transient ischemic attack
diabetology:
Obesity without diabetes
Diabetes T2
T1 diabetes
Monogenic Diabetes / MODY
African Diabetes
Diabetes secondary to pancreatopathy / liver cirrhosis
Diabetes post transplantation / post immunotherapy
Diabetes associated with Steinert's disease
hepatology: hepatological pathology
nephrology: nephrology