Metabolic Disease Clinical Trials

105 recruitingLast updated: June 17, 2026

There are 105 actively recruiting metabolic disease clinical trials across 28 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4. Top locations include Boston, Massachusetts, United States, Bethesda, Maryland, United States, Ann Arbor, Michigan, United States. Updated daily from ClinicalTrials.gov.


Metabolic Disease Trials at a Glance

105 actively recruiting trials for metabolic disease are listed on ClinicalTrialsFinder across 6 cities in 28 countries. The largest study group is Not Applicable with 48 trials, with the heaviest enrollment activity in Boston, Bethesda, and Ann Arbor. Lead sponsors running metabolic disease studies include Massachusetts General Hospital, Colorado State University, and University of Michigan.

Browse metabolic disease trials by phase

Treatments under study

About Metabolic Disease Clinical Trials

Looking for clinical trials for Metabolic Disease? There are currently 59 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metabolic Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metabolic Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 105 trials

Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

ObesityCardiomyopathyLi-Fraumeni Syndrome+3 more
National Heart, Lung, and Blood Institute (NHLBI)5,000 enrolled3 locationsNCT01143454
Recruiting
Phase 1

Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity

Cardiometabolic disease
Amgen80 enrolled9 locationsNCT06585462
Recruiting
Phase 1

Assess the Safety and Tolerability of SNS851 in Healthy Participants

Metabolic Disease
Oneness Biotech Co., Ltd.52 enrolled1 locationNCT07417124
Recruiting
Phase 2

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

ObesityBody WeightOverweight+5 more
Pfizer872 enrolled48 locationsNCT07575932
Recruiting

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

Metabolic DiseaseAutism Spectrum DisorderCognitive Disorder
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)19 enrolled1 locationNCT05600946
Recruiting
Not Applicable

Exercise Effects on Adipose Tissue Structure and Function

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan46 enrolled1 locationNCT04812314
Recruiting

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

ObesityInsulin ResistanceMetabolic Disease+2 more
University of Michigan175 enrolled1 locationNCT06007404
Recruiting
Not Applicable

Continence, Sexual Function, Fitness and the Health of Men After Surgery for Prostate Cancer

Prostate CancerIncontinenceMetabolic Disease
University of Alberta106 enrolled1 locationNCT06072911
Recruiting

Signature of the Risk Profile of Mortality in a Hospital Cohort of Patients With Metabolic Diseases

Metabolic Disease
University Hospital, Lille10,000 enrolled3 locationsNCT04194372
Recruiting
Phase 1

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

HypercholesterolaemiaMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG90 enrolled18 locationsNCT07491172
Recruiting
Not Applicable

Impact of NMES and HPRO on Recovery After SAH- Pilot Study

InflammationSubarachnoid HemorrhageMuscle Atrophy+1 more
University of Maryland, Baltimore30 enrolled1 locationNCT03201094
Recruiting
Phase 1

FES Cycling With BFR in the Spinal Cord Injury Population

Spinal Cord InjuryMetabolic Diseases, Type 2 Diabetes, Cardiovascular DiseaseCardio Vascular Disease
Dr. B. Catharine. Craven6 enrolled1 locationNCT07588503
Recruiting

Alzheimer"s Imaging Biomarkers in Obesity

ObesityMetabolic DiseaseAlzheimer Disease
Cyrus A Raji240 enrolled1 locationNCT05077579
Recruiting
Not Applicable

Blood Lipid Responses to Diet Macronutrients

Nutritional and Metabolic Diseases
University of Oxford60 enrolled2 locationsNCT05973539
Recruiting
Not Applicable

Health Chat for Empowerment-based Lifestyle Planning for Cardiometabolic Multimorbidity

Cardiometabolic DiseasesMultimorbidity
The University of Hong Kong232 enrolled3 locationsNCT07158697
Recruiting

Cardiometabolic Disease and Substrate Metabolism

Insulin ResistancePregnancyPregnancy Complications+9 more
University of Tennessee Graduate School of Medicine50 enrolled1 locationNCT07565727
Recruiting

Evaluation of Children With Endocrine and Metabolic-Related Conditions

Metabolic DiseaseAdrenal InsufficiencyBone Diseases, Metabolic+2 more
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)15,000 enrolled1 locationNCT02769975
Recruiting

Study on Construction of Whole Lifecycle Cohort, Big Data Management and Clinical Prognosis of Cardio-Renal-Metabolic (CKM) Syndrome

Chronic Kidney DiseaseMetabolic DiseasesCardiovascular Diseases (CVD)+1 more
First Affiliated Hospital of Fujian Medical University8,000 enrolled1 locationNCT07547098
Recruiting

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

Metabolic DiseaseOrganic AcidemiaPropionic Acidemia
National Human Genome Research Institute (NHGRI)1,045 enrolled2 locationsNCT02890342
Recruiting

Natural History of the Human Biological Response to Environmental Exposure and Injury

Metabolic DiseaseInflammationNormal Controls
National Institute of Environmental Health Sciences (NIEHS)2,000 enrolled1 locationNCT04888923