Metabolic Disease Clinical Trials

57 recruiting

Metabolic Disease Trials at a Glance

91 actively recruiting trials for metabolic disease are listed on ClinicalTrialsFinder across 6 cities in 25 countries. The largest study group is Not Applicable with 42 trials, with the heaviest enrollment activity in Boston, Bethesda, and Ann Arbor. Lead sponsors running metabolic disease studies include Massachusetts General Hospital, Colorado State University, and University of Michigan.

Browse metabolic disease trials by phase

Treatments under study

About Metabolic Disease Clinical Trials

Looking for clinical trials for Metabolic Disease? There are currently 57 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metabolic Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metabolic Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 91 trials

Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

ObesityCardiomyopathyLi-Fraumeni Syndrome+3 more
National Heart, Lung, and Blood Institute (NHLBI)5,000 enrolled3 locationsNCT01143454
Recruiting
Not Applicable

Health Chat for Empowerment-based Lifestyle Planning for Cardiometabolic Multimorbidity

Cardiometabolic DiseasesMultimorbidity
The University of Hong Kong240 enrolled3 locationsNCT07158697
Recruiting

Evaluation of Children With Endocrine and Metabolic-Related Conditions

Metabolic DiseaseAdrenal InsufficiencyBone Diseases, Metabolic+2 more
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)15,000 enrolled1 locationNCT02769975
Recruiting

Study on Construction of Whole Lifecycle Cohort, Big Data Management and Clinical Prognosis of Cardio-Renal-Metabolic (CKM) Syndrome

Chronic Kidney DiseaseMetabolic DiseasesCardiovascular Diseases (CVD)
First Affiliated Hospital of Fujian Medical University8,000 enrolled1 locationNCT07547098
Recruiting

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

Metabolic DiseaseOrganic AcidemiaPropionic Acidemia
National Human Genome Research Institute (NHGRI)1,045 enrolled2 locationsNCT02890342
Recruiting
Not Applicable

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Insulin ResistanceHyperinsulinismDepression+5 more
Colorado State University300 enrolled2 locationsNCT05543083
Recruiting

Natural History of the Human Biological Response to Environmental Exposure and Injury

Metabolic DiseaseInflammationNormal Controls
National Institute of Environmental Health Sciences (NIEHS)2,000 enrolled1 locationNCT04888923
Recruiting
Not Applicable

Metabolic Adaptations to Weight Loss With and Without Exercise

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan68 enrolled1 locationNCT05806801
Recruiting
Not Applicable

Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

InsomniaCardiovascular DiseasesMetabolic Disease+1 more
University of California, Los Angeles167 enrolled1 locationNCT05516277
Recruiting
Phase 4

GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

Genetic PredispositionType 2 DiabetesMetabolic Diseases
Massachusetts General Hospital125 enrolled1 locationNCT06003153
Recruiting
Not Applicable

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

Cardiovascular DiseasesCardiometabolic DiseasesNatriuretic Peptides+1 more
University of Alabama at Birmingham200 enrolled1 locationNCT05216042
Recruiting
Phase 1

Assess the Safety and Tolerability of SNS851 in Healthy Participants

Metabolic Disease
Oneness Biotech Co., Ltd.52 enrolled1 locationNCT07417124
Recruiting
Phase 1

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

HypercholesterolaemiaMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG90 enrolled18 locationsNCT07491172
Recruiting

Molecular Prediction of Development, Progression or Complications of Kidney, Immune or Transplantation-related Diseases

CancerMetabolic DiseaseChronic Kidney Diseases+3 more
University Hospital, Toulouse5,000 enrolled1 locationNCT05318196
Recruiting

Evaluation of Therapeutic Adherence Among Patients Followed in the Department of Hereditary Metabolic Diseases at Necker Hospital

Metabolic Diseases
Assistance Publique - Hôpitaux de Paris200 enrolled1 locationNCT07356557
Recruiting
Phase 1Phase 2

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Not Applicable

NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

Heart FailureType 2 DiabetesDiabetic Cardiomyopathy+1 more
University of Texas Southwestern Medical Center300 enrolled1 locationNCT06593327
Recruiting

Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

ObesityMetabolic DiseaseDelayed Gastric Emptying Following Procedure+2 more
Christopher C. Thompson, MD, MSc30 enrolled1 locationNCT05711758
Recruiting

Magnetic Resonance Imaging in Metabolic Diseases

Metabolic Diseases
University of Ulm126 enrolled1 locationNCT06709846
Recruiting
Not Applicable

The Satiety Control Optimization by Nutritional Enhancement Study

Metabolic Diseases, Type 2 Diabetes, Cardiovascular Disease
University College Cork24 enrolled1 locationNCT07420023