RecruitingNCT04207580

A National Prospective Cohort of Patients With Idiopathic Nephrotic Syndrome Beginning in Childhood.


Sponsor

University Hospital, Limoges

Enrollment

1,180 participants

Start Date

Mar 13, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

Pediatric idiopathic nephrotic syndrome (INS) is a rare disease for which the optimal therapeutic strategy has not yet been defined. A network of clinicians treating complicated forms of this disease (grouped within the Société de Néphrologie Pédiatrique, SNP) exists, but to date there is no prospective cohort following up these patients that would facilitate the development of cohort-nested trials. This absence of structured follow up makes it difficult to set up prospective studies. The main objective is to create a prospective cohort of pediatric INS patients to collect cases treated in SNP centers, to study their epidemiological characteristics, and to provide a basis for comparison for future cohort-nested trials.


Eligibility

Max Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a national French cohort study following children diagnosed with idiopathic nephrotic syndrome (INS) — a kidney disorder where the kidneys leak too much protein into the urine, causing swelling, low protein levels in the blood, and increased infection risk. 'Idiopathic' means the cause is unknown, which makes it harder to predict outcomes or choose the best treatment. By tracking hundreds of children over time, researchers hope to understand what factors affect long-term outcomes — such as whether children go into remission, how many relapses they have, and what treatments work best. This data will help improve care guidelines for all children with this condition in France and internationally. You may be eligible if: - Your child is under 18 years old - Your child was diagnosed with idiopathic nephrotic syndrome after January 1, 2018 - Your child has been seen by a pediatrician who is a member of the Society of Pediatric Nephrology (SPN) - You reside in France and are covered by French social security You may NOT be eligible if: - The patient or legal guardians refuse to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERInclusion and follow up of pediatric patients with an idiopathic nephrotic syndrome,

The study consists in collecting clinical, biological, psychological and social data of INS pediatric patients. A bio collection is also created: blood, urine, hair and nails will be collected at the beginning of the INS (before starting immunosuppressive treatment).


Locations(48)

CH d'Agen

Agen, France

CHU d'Amiens

Amiens, France

CHU d'Auxerre

Auxerre, France

CH de la côte basque

Bayonne, France

CHU de Besançon

Besançon, France

CHU de Boredeaux

Bordeaux, France

CHU de Brest

Brest, France

HCL Lyon

Bron, France

CH de Chambéry

Chambéry, France

CHU de Clermont Ferrand

Clermont-Ferrand, France

CHU de Dijon

Dijon, France

CH du Val d'Ariège

Foix, France

CH de la Rochelle

La Rochelle, France

CHU de Grenoble

La Tronche, France

CH de Versaille

Le Chesnay, France

CHU de Lille - Hôpital Jeanne de Flandre

Lille, France

Limoges Hospital

Limoges, France

CHU de Marseille - Timone enfants

Marseille, France

CH de Macon

Mâcon, France

CHU de Montpellier - Hôpital Arnaud de Villeneuve

Montpellier, France

CHU de Nancy

Nancy, France

CHU de Nantes

Nantes, France

CHU de Nice - Hopital Larchet

Nice, France

CHU de Nimes

Nîmes, France

AP-HP Trousseau

Paris, France

AP-HP Robert Debré

Paris, France

AP-HP Necker

Paris, France

CH de Pau

Pau, France

CH de Perpignan

Perpignan, France

CH de Périgueux

Périgueux, France

CHU de Poitiers

Poitiers, France

CH d'Annecy

Pringy, France

CHU de Reims

Reims, France

CHU de Rennes

Rennes, France

CH de Roanne

Roanne, France

CH de Roubaix

Roubaix, France

CHU de Rouen

Rouen, France

CHU de Saint-Etienne

Saint-Priest-en-Jarez, France

CH de Sallanches

Sallanches, France

CHRU de Strasbourg

Strasbourg, France

CH de Toulon

Toulon, France

CHU de Toulouse

Toulouse, France

CHU de Tours

Tours, France

CH de Vannes

Vannes, France

CH de Villefranche

Villefranche-sur-Saône, France

CH de Voiron

Voiron, France

CHU de La Réunion - Félix Guyon

Saint-Denis, Reunion

CHU de la Réunion

Saint-Pierre, Reunion

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NCT04207580


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