RecruitingPhase 3NCT04214990

Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients

Effect of Low-dose Aspirin for Stomach Cancer Prevention After Endoscopic Resection of Gastric Neoplasm (EASTERN): a Randomized Controlled Trial


Sponsor

National Cancer Center, Korea

Enrollment

1,700 participants

Start Date

Feb 15, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This study aimed to investigate the effect of low-dose (100 mg) asprin on the prevention of gastric cancer in the early gastric cancer patients with negative H. pylori status who underwent endoscopic submucosal dissection.


Eligibility

Min Age: 19 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This trial tests whether taking low-dose aspirin after endoscopic removal of early stomach cancer or high-grade stomach lesions can help prevent new stomach cancer from developing. **You may be eligible if...** - You are a man or woman aged 19–70 - You had an endoscopic procedure to remove high-grade stomach lesions or early gastric cancer - Your pathology results met criteria for complete removal - Your H. pylori status is negative or has been successfully treated **You may NOT be eligible if...** - You already take aspirin to prevent heart disease or stroke - You take anticoagulants or antiplatelet drugs for treatment - You have had stomach surgery before - You have serious heart, liver, kidney, or lung conditions - You have conditions that increase your risk of bleeding (aneurysm, varices, hemophilia) - You have active peptic ulcers or are being treated for another cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAspirin 100mg

Daily aspirin 100 mg for 5 years

DRUGPlacebo oral tablet

Daily placebo for 5 years


Locations(10)

Pusan National University Hospital

Busan, South Korea

Kosin University Gospel Hospital

Busan, South Korea

Hallym University Chuncheon Sacred Heart Hospital

Chuncheon, South Korea

Kyungpook National University Chilgok Hospital

Daegu, South Korea

National Cancer Center

Goyang, South Korea

Chonnam National University Hospital

Gwangju, South Korea

Incheon St.Mary's Hospital/The Catholic University

Incheon, South Korea

Chung-Ang University Hospital

Seoul, South Korea

SMG-SNU Boramae Medical Center

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

View Full Details on ClinicalTrials.gov

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NCT04214990


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