RecruitingNCT04232566
Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity- AIM 1
Sponsor
Mayo Clinic
Enrollment
60 participants
Start Date
Feb 20, 2022
Study Type
OBSERVATIONAL
Conditions
Summary
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.
Eligibility
Min Age: 30 YearsMax Age: 70 Years
Inclusion Criteria6
- Undergoing gastric bypass surgery
- Confirmed AUROC F=0 or F>2 liver fibrosis
- Age 30-70 years
- BMI greater than 40 kg/m2
- Negative pregnancy test (female only)
- Lab Values: Normal TSH
Exclusion Criteria11
- Autoimmune diseases
- Hepatitis B or C positive
- Heavy alcohol use
- Active smoking history
- Active cancer history
- History of asthma
- History of COPD
- Taking Plavix or Coumadin
- Blood donation within past 2 months
- Glucocorticoid Therapy
- Taking antihistamine on regular basis
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Interventions
PROCEDUREBariatric surgery
Evaluate liver fibrosis by elastography before gastric bypass surgery.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04232566
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