RecruitingNCT04238299

Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease

Sponsor

University Hospitals of Derby and Burton NHS Foundation Trust

Enrollment

450 participants

Start Date

Jun 1, 2021

Study Type

OBSERVATIONAL

Conditions

Chronic Kidney Diseases

Summary

Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease (CKD)? Aims and objectives: 1. To establish a multiparametric renal MRI protocol in CKD cohorts. 2. To use multiparametric MRI to characterise people with and without CKD progression. 3. To compare multiparametric renal MRI with 'gold-standard' renal biopsy to determine pathological processes of CKD progression that are detectable by MRI.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria3

Age 18-75 years
CKD category G3-4 or CKD category G1-2 with overt albuminuria (urine ACR\>30mg/mmol)
Capable of giving informed consent

Exclusion Criteria7

Autosomal dominant polycystic kidney disease (ADPKD)
Glomerulonephritis (GN) actively receiving immunosuppression, or within the preceding 90 days.
Multiple myeloma (MM)
Acute Kidney Injury (AKI) within the preceding 90 days
Solid organ transplant
Known single kidney
Contraindications to MRI (e.g. permanent pacemaker, metallic foreign bodies, claustrophobia etc.)

Interventions

DIAGNOSTIC_TESTMultiparametric renal MRI

Localiser scans; Kidney volume; Longitudinal (T1) relaxation time mapping; Diffusion weighted imaging (DWI); Phase Contrast MRI; Arterial spin labelling (ASL); Blood Oxygen Level Dependent (BOLD) mapping