RecruitingPhase 4NCT04258488

Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement

Randomized, Evaluation of Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement

Sponsor

Joon Bum Kim

Enrollment

1,300 participants

Start Date

Feb 21, 2022

Study Type

INTERVENTIONAL

Conditions

Thromboembolism AORTIC VALVE DISEASES

Summary

This study evaluates the long-term anticoagulation with oral factor Xa inhibitor versus vitamin K antagonist in patients receiving a mechanical aortic valve replacement.

Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Rivaroxaban Oral Tablet and a drug called Vitamin K antagonist(warfarin) for people with aortic valve diseases and thromboembolism. The study is currently recruiting participants at 15 locations. People eligible for this study include aged 19 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRivaroxaban Oral Tablet

For 12months, Rivaroxaban oral tablet 20mg once daily For renal disorder subjects\_creatinine clearance 15-49 mL/min, 15mg once daily

DRUGVitamin K antagonist(warfarin)

For 12months, keep the international normalized ratio (INR) 1.7-3.0

Locations(16)

Buchen Sejong Hospital

Bucheon-si, South Korea

Dong-A University Hospital

Busan, South Korea

Keimyung University Dongsan Hospital

Daegu, South Korea

GangNeung Asan Hospital

Gangneung, South Korea

Chonnam National University Hospital

Gwangju, South Korea

Seoul National University Bundang Hospital

Seongnam, South Korea

Asan Medical Center

Seoul, South Korea

Korea University Anam Hospital

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital

Seoul, South Korea

Ajou University Hospital

Suwon, South Korea

St. Vincent's Hospital, Catholic University of Korea

Suwon, South Korea

Eulji University Uijeongbu Hospital

Uijeongbu-si, South Korea

Ulsan University Hospital

Ulsan, South Korea

Pusan National University Yangsan Hospital

Yangsan, South Korea

View Full Details on ClinicalTrials.gov

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NCT04258488

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