RecruitingNot ApplicableNCT04263285

Treatment of Depression Post-SCI

Treatment of Depression Post-SCI: Retrospective Analysis and Feasibility Trial


Sponsor

Medical University of South Carolina

Enrollment

14 participants

Start Date

Oct 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are effective. This study will investigate the safety and impact of a novel method for treating depression called repetitive transcranial magnetic stimulation (rTMS). rTMS is a type of non-invasive brain stimulation. Fourteen individuals with a cervical or thoracic level SCI and depression will complete an approved treatment plan using rTMS. Participants will be treated using rTMS five days a week for four weeks. After four weeks of treatment, the study team will review the safety of rTMS and assess changes in depressive symptoms. If the results are positive, larger studies can be designed to develop better treatment options for individuals with SCI and depression.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique — can treat depression in people who have had a spinal cord injury (SCI), using the same FDA-approved approach used for the general population. **You may be eligible if:** - You are between 18 and 70 years old - You have had an incomplete cervical or thoracic spinal cord injury at least 6 months ago - You have been diagnosed with major depressive disorder - You have at least partial thumb movement (needed for calibrating the TMS device) - You have been stable on (or off) antidepressants for at least 4–6 weeks **You may NOT be eligible if:** - You have other neurological diseases or dementia - You have significant cognitive impairment - You have a history of major head trauma - You have a pacemaker, implanted brain or spinal stimulator, or defibrillator Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICErTMS

The study team will deliver rTMS five days a week for four weeks, according to a specific and approved protocol for participant positioning, motor threshold determination, and dosing.


Locations(1)

Medical University of South Carolina

Charleston, South Carolina, United States

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NCT04263285


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