Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

This study is using advanced MRI scans to track changes in normal tissues (like jaw bone and soft tissues) during and after radiation treatment in patients with cancers of the mouth, throat, or skull base, to better predict and prevent radiation-related complications such as bone damage (osteonecrosis). **You may be eligible if:** - You are 18 or older and in good general health - You have a confirmed cancer of the oral cavity, oropharynx, or skull base and are about to receive radiation therapy - OR you have already had radiation and developed a complication called osteoradionecrosis (ORN) or medication-related osteonecrosis of the jaw (MRONJ) **You may NOT be eligible if:** - You are unable to tolerate the specific types of MRI scans used in this study (DW-MRI or DCE-MRI) - You have other conditions preventing MRI participation Talk to your doctor to see if this trial is right for you.