Forced Oscillometry in Infants With Bronchopulmonary Dysplasia

This study uses a technique called forced oscillometry (FOT) to measure lung function in premature babies diagnosed with bronchopulmonary dysplasia (BPD). BPD is a chronic lung disease that develops in premature infants — especially those born very early — whose lungs needed assistance to breathe (ventilation or oxygen support) after birth. Unlike standard lung function tests that require deep breathing or effort from the patient, forced oscillometry works by sending gentle sound waves into the airway and measuring how the lungs respond. This makes it suitable for use in very young infants who cannot cooperate. The goal is to validate this measurement technique in this vulnerable population, compare readings between babies with and without BPD, and follow some infants up to 2 years of age. The study includes preterm infants with BPD, as well as healthy full-term infants for comparison. You may be eligible if: - Your baby is a premature infant with bronchopulmonary dysplasia (BPD), in room air or on low-flow oxygen - OR your baby is a healthy full-term infant (36+ weeks gestational age) under 4 weeks old - OR your child is a former preterm infant (born before 32 weeks), seen before 2 years of age, diagnosed with BPD You may NOT be eligible if: - Your baby requires a ventilator or non-invasive positive pressure breathing support - Your baby has BPD along with a genetic diagnosis or major birth defect Talk to your doctor to see if this trial is right for you.