RecruitingNCT04286841

The Real World Study of Neoadjuvant Immunotherapy in Early Stage NSCLC in China


Sponsor

Guangdong Association of Clinical Trials

Enrollment

100 participants

Start Date

May 1, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

Several published clinical trials have shown the superiority of immunotherapy in neoadjuvant setting. Here we conducted this real world study to see whether neoadjuvant immunotherapy would bring MPR and survival benefits in NSCLC, for example, single agent immunotherapy or immunotherapy combination with chemotherapy. Furthermore biomarker analysis would be also performed to achieve personalized neoadjuvant immunotherapy.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This real-world study follows patients in China with early-stage non-small cell lung cancer (NSCLC) who receive immunotherapy before surgery (called neoadjuvant therapy). It observes how well this approach works in actual clinical practice outside of controlled trials. **You may be eligible if...** - You are 18 or older - You have been diagnosed with non-small cell lung cancer at stage II or IIIA that is potentially removable by surgery - Your cancer does not have EGFR or ALK mutations (specific genetic changes) - You are in good physical condition (ECOG score 0-1) - Your lung function is adequate for surgery **You may NOT be eligible if...** - Your cancer has the EGFR mutation or ALK rearrangement - Your cancer is at a stage that is not surgically removable - You are in poor physical condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGImmunotherapy

Patients in this group should be histologically confirmed potentially resectable NSCLC with stage II-IIIA. Furthermore patients would receive either single agent immunotherapy or immunotherapy combined with chemotherapy.


Locations(1)

Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences

Guangzhou, Guangdong, China

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NCT04286841


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