Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
Boston Children's Hospital
100 participants
May 31, 2022
OBSERVATIONAL
Conditions
Summary
The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels 2. Understand the correlation between GABA and inflammatory cytokines (and/or activated monocytes) and 3. Assess the correlation between thrombosis and monocyte activation in patients undergoing cardiac surgery under CPB and at risk of thrombosis.
Eligibility
Inclusion Criteria1
- Patients (all ages) undergoing complex cardiac surgical procedures with CPB.
Exclusion Criteria3
- undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent
- patient in a moribund condition American Society of Anesthesiology (ASA 5) -patient with a hematological and/or oncological disease
- Jehovah witnesses.
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Interventions
Will utilize the discarded blood from routine clinical blood samples to evaluate the role of immune cells in coagulopathy.
Locations(1)
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NCT04299828