Trial of Ixazomib for Kaposi Sarcoma

This study is testing whether ixazomib (an oral drug that blocks a cellular process cancer cells rely on to survive) can treat Kaposi sarcoma, a cancer that causes skin lesions and can affect internal organs. **You may be eligible if...** - You have a confirmed diagnosis of cutaneous (skin) Kaposi sarcoma - You have at least 5 measurable skin lesions (or lesions with a total surface area of at least 700 mm²) - You have documentation of your HIV status (positive or negative) - If HIV-positive, your virus must be well controlled on medication - Your blood counts and organ function meet minimum requirements **You may NOT be eligible if...** - You have untreated or uncontrolled HIV - Your Kaposi sarcoma does not have measurable skin lesions - You have serious organ dysfunction - You are pregnant or breastfeeding - You are on medications that strongly interact with ixazomib Talk to your doctor to see if this trial is right for you.