Chemotherapy Combined With Immunotherapy in HER 2 Insertion or Amplification Advanced NSCLC

This study is looking at how well chemotherapy combined with immunotherapy works in people with advanced non-small cell lung cancer that has a specific genetic change: a HER2 gene insertion or amplification. Researchers want to understand the best first-line treatment for this subgroup of lung cancer patients. **You may be eligible if...** - You are 18 years or older - You have advanced, non-squamous non-small cell lung cancer confirmed by biopsy - Your tumor has a HER2 gene insertion or amplification - You have not received any prior cancer treatment - You are planning to receive chemotherapy, with or without a PD-1 immunotherapy drug **You may NOT be eligible if...** - You have already received treatment for your lung cancer - You have a medical condition that makes chemotherapy unsafe - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.