RecruitingNot ApplicableNCT04332692

Acute Heart Failure - COngestion Discharge Evaluation

Acute Heart Failure - COngestion Discharge Evaluation. Évaluation de la Congestion à la Sortie d'Hospitalisation Pour Insuffisance Cardiaque aiguë.


Sponsor

Central Hospital, Nancy, France

Enrollment

110 participants

Start Date

Jul 15, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

Acute heart failure (AHF) is a major public health problem, associated with a 40% risk of death or re-hospitalisation at 3 months. This risk is significantly increased by insufficient decongestion at the end of hospitalisation for AHF assessed by a standardised clinical score, a natriuretic peptide dosage or by cardiac and pulmonary ultrasound . Adapting treatment according to lung congestion assessed by implantable devices (not reimbursed in France) improves the prognosis. However, due to the lack of a standardised congestion assessment, therapeutic adaptation in acute heart failure is currently empirical. The best multimodality approach to congestion evaluation is uncertain.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a new method to help doctors decide when heart failure patients are ready to be safely discharged from the hospital. Using lung ultrasound to measure fluid buildup, researchers want to see if this approach better predicts who is at risk of readmission soon after going home. **You may be eligible if...** - You are 18 years or older - You have been admitted to hospital for acute (sudden-onset) heart failure - You are currently considered clinically ready for discharge - You are covered by a social security scheme (French study requirement) **You may NOT be eligible if...** - You have a serious co-existing illness with a life expectancy of 3 months or less - You are on dialysis or have severely reduced kidney function - You have had lung surgery (lobectomy or pneumonectomy) - You have severe lung disease (emphysema, pulmonary fibrosis, etc.) that would interfere with ultrasound imaging - You are pregnant or breastfeeding - You are unable to give consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREClinical examination centered on congestion

Clinical examination centered on congestion (ASCEND, NYHA and Ambrosy Score) will be performed before discharge from hospital

PROCEDURECardiac, pulmonary, peritoneal, jugular, renal Doppler ultrasounds and liver elastography

Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography will be performed before discharge from hospital

PROCEDUREBlood sample retrieved for biological assessment and biobanking

Blood sample retrieved for biological assessment and biobanking will be performed before discharge from hospital

PROCEDURETelephone follow-up

Telephone follow-up will be performed 3, 12 and 24 months after discharge from hospital

BEHAVIORALKansas City Cardiomyopathy Questionnaire (KCCQ)

Questionnaire centered on patient's quality of life at discharge and 3, 12 and 24 months after discharge


Locations(1)

CHRU de Nancy

Vandœuvre-lès-Nancy, France

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NCT04332692


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