RecruitingNot ApplicableNCT04334135

The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function


Sponsor

Auburn University

Enrollment

60 participants

Start Date

Oct 2, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen species improves blood pressure and vascular function in individuals with elevated blood pressure and stage 1 hypertension.


Eligibility

Min Age: 19 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether racial differences in how blood vessels function might be linked to a type of cellular stress called mitochondrial reactive oxygen species. Researchers want to understand the biology behind known racial disparities in blood vessel health and the risk of conditions like high blood pressure and stroke. **You may be eligible if...** - You are between 19 and 75 years old - Your blood pressure is no higher than 150/90 mmHg - Your BMI is below 35 kg/m² - You are free from diabetes, kidney disease, lung disease, and cardiovascular disease - You have not smoked or used tobacco in the past 12 months - You are physically able to exercise and give blood samples **You may NOT be eligible if...** - You have a history of heart disease, stroke, cancer, diabetes, or kidney disease - You have high or low blood pressure outside the stated range - You have a BMI of 30 or above (considered obese) - You smoke or use tobacco - You are pregnant or breastfeeding - You are allergic to MitoQ (the supplement being studied) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTMitoQ

Four to eight 20mg capsules (depending on body mass)


Locations(1)

Kinesiology Building

Auburn, Alabama, United States

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NCT04334135


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