RecruitingNot ApplicableNCT04343430

Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation

Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation: Evaluation de la Congestion à la Sortie d'Hospitalisation Pour Insuffisance Cardiaque aiguë à Fraction d'éjection préservée


Sponsor

Central Hospital, Nancy, France

Enrollment

170 participants

Start Date

Aug 29, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The AHF-CODE preserved study is a prospective, non-randomized, monocenter study performed in patients with heart failure with preserved ejection fraction admitted for worsening heart failure. The main objective of the AHF-CODE preserved study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating the best way to assess fluid buildup (congestion) in patients with heart failure and a relatively preserved pumping function, just before they are discharged from hospital. The goal is to prevent readmission by ensuring patients are truly ready to go home. **You may be eligible if:** - You were hospitalized for acute (sudden) heart failure - Your heart's pumping function (ejection fraction) is 50% or higher — this is called "preserved" ejection fraction - Your doctors consider you ready to be discharged - You are 18 years or older - You are enrolled in a French social security scheme **You may NOT be eligible if:** - You have a serious illness with a life expectancy of 3 months or less - You are on dialysis or have very poor kidney function - You have had lung surgery (removal of part or all of a lung) - You have severe lung or chest conditions that make ultrasound imaging unreliable (such as severe emphysema or pulmonary fibrosis) - You are pregnant, just gave birth, or are breastfeeding - You are under legal guardianship Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREClinical examination centered on congestion

Clinical examination centered on congestion (ASCEND, NYHA and Ambrosy Score) will be performed before discharge from hospital

PROCEDURECardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography

Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography will be performed before discharge from hospital

PROCEDUREBiological: Blood sample retrieved for biological assessment and biobanking

Blood sample collection will be performed before discharge from hospital

PROCEDURETelephone interview

Telephone interview will be performed at 3, 12 months and 24 months after discharge from Hospital

BEHAVIORALKansas City Cardiomyopathy Questionnaire (KCCQ)

Questionnaire centered on patient's quality of life at discharge and 3, 12 and 24 months after discharge


Locations(1)

CHRU de Nancy

Vandœuvre-lès-Nancy, France

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NCT04343430


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