RecruitingNot ApplicableNCT04343443

Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation

Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation: Evaluation de la Congestion à la Sortie d'Hospitalisation Pour Insuffisance Cardiaque aiguë à Fraction d'éjection altérée ou modérément altérée


Sponsor

Central Hospital, Nancy, France

Enrollment

200 participants

Start Date

Aug 21, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure. The main objective of the AHF-CODE study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating how to best measure fluid buildup (congestion) in patients with heart failure and reduced pumping function, just before hospital discharge. The aim is to ensure patients are truly stable before going home and to reduce the risk of readmission. **You may be eligible if:** - You were hospitalized for acute (sudden-onset) heart failure - Your heart's pumping function (ejection fraction) is below 50% — known as "reduced" ejection fraction - Your doctors think you are ready to be discharged - You are 18 years or older - You are enrolled in a French social security scheme **You may NOT be eligible if:** - You have a serious illness with a life expectancy of 3 months or less - You are on dialysis or have very poor kidney function - You have had lung surgery (removal of part or all of a lung) - You have severe lung conditions that make ultrasound imaging unreliable - You are pregnant, just gave birth, or are breastfeeding - You are under legal guardianship Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREClinical examination centered on congestion

Clinical examination centered on congestion (ASCEND, NYHA and Ambrosy Score) will be performed before discharge from hospital

PROCEDURECardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography

Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography will be performed before discharge from hospital

PROCEDUREBiological: Blood sample retrieved for biological assessment and biobanking

Blood sample collection will be performed before discharge from hospital

PROCEDURETelephone interview

Telephone interview will be performed at 3, 12 months and 24 months after discharge from hospital

BEHAVIORALKansas City Cardiomyopathy Questionnaire (KCCQ)

Questionnaire centered on patient's quality of life at discharge and 3, 12 and 24 months after discharge


Locations(1)

CHRU de Nancy

Vandœuvre-lès-Nancy, France

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NCT04343443


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