Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS)

This study investigates whether vitamin D supplementation can improve symptoms and metabolic markers in teenage girls with polycystic ovary syndrome (PCOS) who also have low vitamin D levels. PCOS is a hormonal disorder affecting the ovaries and causing irregular periods, excess androgens (male hormones), and sometimes infertility. Vitamin D deficiency is common in PCOS and may worsen hormonal imbalances. Participants receive vitamin D replacement and are monitored for changes in hormone levels, menstrual regularity, and psychological wellbeing. The study addresses both the physical and mental health burden of PCOS in adolescence. You may be eligible if: - You are a postmenarchal female aged 13-21 - You have been diagnosed with PCOS based on modified Rotterdam criteria - Your vitamin D level is between 6-29 ng/mL (deficient range) You may NOT be eligible if: - Your high androgen levels are caused by something other than PCOS (e.g., adrenal tumor) - You have chronic kidney disease - You have a calcium or vitamin D metabolism disorder Talk to your doctor to see if this trial is right for you.