Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

Inclusion Criteria7

• Diagnosis of a schizophrenia-spectrum disorder or mood disorder with psychotic features as determined using the Structured Clinical Interview for the DSM-5.
• Less than 5 years since the onset of frank psychotic symptoms as determined using the Symptom Onset in Schizophrenia Inventory .
• No evidence of a pre-existing intellectual disability defined as a premorbid IQ \>70 as estimated using the Reading subtest of the Wide Range Achievement Test-4.
• Ages 15-35
• Non-smoker for past six months
• Absence of suicidal ideation or behavior over the past month as assessed by the Columbia Suicide Severity Rating Scale
• The American Association for Respiratory Care notes that "no absolute contraindications to oxygen therapy exist when indications \[for oxygen therapy\] are present."