First-episode Psychosis Clinical Trials

9 recruitingLast updated: July 25, 2026

There are 9 actively recruiting first-episode psychosis clinical trials across 3 countries. Studies span Not Applicable, Phase 4. Top locations include Lauderdale Lakes, Florida, United States, New York, New York, United States, Grand Rapids, Michigan, United States. Updated daily from ClinicalTrials.gov.


First-episode Psychosis Trials at a Glance

9 actively recruiting trials for first-episode psychosis are listed on ClinicalTrialsFinder across 6 cities in 3 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Lauderdale Lakes, New York, and Grand Rapids. Lead sponsors running first-episode psychosis studies include Northwell Health, Columbia University, and John Jay College of Criminal Justice, City University of New York.

Browse first-episode psychosis trials by phase

Treatments under study

About First-episode Psychosis Clinical Trials

Looking for clinical trials for First-episode Psychosis? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new First-episode Psychosis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about First-episode Psychosis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 19 of 9 trials

Recruiting
Not Applicable

Digital Strategies to Advance Help-Seeking - Aim 3

Early PsychosisFirst-episode PsychosisClinical High Risk
Columbia University25,000 enrolled1 locationNCT06774417
Recruiting
Not Applicable

Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode

First-episode Psychosis
University Hospital, Brest217 enrolled5 locationsNCT05384392
Recruiting
Not Applicable

Recovery With Exogenous Ketones and Antipsychotics

First-episode Psychosis
Université de Sherbrooke15 enrolled1 locationNCT07122531
Recruiting

Digital Strategies to Advance Help-Seeking Aim 1 and 2

Early PsychosisFirst-episode PsychosisClinical High Risk
Columbia University25,000 enrolled1 locationNCT06774430
Recruiting
Not Applicable

Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

SchizophreniaPsychosisFirst-episode Psychosis
Nicholas Breitborde20 enrolled1 locationNCT04368039
Recruiting
Not Applicable

Pilot RCT of Self-stigma Treatment for First Episode Psychosis

YouthFirst-episode Psychosis
John Jay College of Criminal Justice, City University of New York40 enrolled1 locationNCT04889911
Recruiting

Early-Phase Schizophrenia: Practice-based Research to Improve Outcomes

First-episode Psychosis
Northwell Health700 enrolled1 locationNCT04004364
Recruiting
Phase 4

Artificial Intelligence to Measure Adherence to Oral Medication

First-episode Psychosis
Northwell Health200 enrolled5 locationsNCT04046497
Recruiting
Phase 4

Disengagement in CSC: Identifying Those at Risk and Addressing Their Needs

First-episode Psychosis
Northwell Health300 enrolled3 locationsNCT04005378