RecruitingNot ApplicableNCT04370730

Dimensional and Developmental Profiles of Psychosis in Children and Adolescents

Dimensional and Developmental Approach to Psychotic Episodes in Children and Adolescents: Impact on Clinical Management


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

200 participants

Start Date

Jun 2, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Five collaborating sites in France will study the broad spectrum of schizophrenia in children and adolescents. Patients will be studied with diagnostic interviews, developmental histories, dimensional clinical ratings, comprehensive cognitive assessments, neuroimaging and DNA (copy number variant) analyses (in families and patients who agree), and follow-up of course of illness, cognitive status and treatment response to specific antipsychotic drugs. The goal of the study is to test a prior hypothesis about clinical subgroups in this population and to test whether these subgroups predict antipsychotic medication response.


Eligibility

Min Age: 7 YearsMax Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study aims to better understand psychosis in children and teenagers by examining its different forms and how it develops over time. Researchers will look at clinical, genetic, and brain imaging data to improve how psychotic disorders are diagnosed and treated in young people. **You may be eligible if...** - You are between 7 and 20 years old and your first psychotic symptoms began between ages 7 and 17 - You have been diagnosed with schizophrenia, schizoaffective disorder, brief psychotic disorder, or depression with psychotic features - You have been hospitalized or are receiving outpatient treatment for a psychotic episode - Parents or siblings may also participate in the genetic part of the study - You are covered by French Social Security **You may NOT be eligible if...** - You have a moderate or severe intellectual disability (IQ below 50) - Your psychosis is caused by a medical condition, medication, or drug use - You have a diagnosis of bipolar disorder - You are under legal guardianship - You have a contraindication to MRI (for the brain imaging part only) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERclinical, neuroimaging and DNA assessments

Selected assessments, including evaluation of treatment response to specific antipsychotic drugs, will be performed at follow-up visits after 1, 3 and 5 years


Locations(6)

Fondation Vallée, Gentilly

Gentilly, France

CHRU de Lille

Lille, France

CHU de Nice

Nice, France

Pitié Salpétrière

Paris, France

CHU de Rouen

Rouen, France

CHU de Rouvray

Rouen, France

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NCT04370730


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