RecruitingNCT07379827

Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)

Effectiveness and Adverse-effect Switch Evaluation

Sponsor

Bristol-Myers Squibb

Enrollment

1,500 participants

Start Date

Feb 26, 2026

Study Type

OBSERVATIONAL

Conditions

Schizophrenia

Summary

The purpose of this study is to describe real-world treatment patterns, effectiveness and adverse events of adults diagnosed with schizophrenia that have initiated xanomeline and trospium chloride (KarXT) treatment in the United States

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This real-world study tracks the effectiveness and side effects of xanomeline and trospium chloride (brand name KarXT), a newly approved antipsychotic medication, in adults with schizophrenia who are switching from or adding to their current antipsychotic treatment. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of schizophrenia - Your doctor has already decided — independent of this study — to treat you with KarXT - You are either starting KarXT and intending to stop your prior medication, or switching to KarXT from a stable regimen of another antipsychotic **You may NOT be eligible if...** - You have not been prescribed KarXT by your doctor as part of your normal clinical care - You are unwilling to follow the study's clinical care and follow-up requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGXanomeline and trospium chloride (KarXT)

According to the product label

Locations(52)

SanRo Clinical Research Group

Bryant, Arkansas, United States

Local Institution - 0047

Anaheim, California, United States

Local Institution - 0003

Anaheim, California, United States

Local Institution - 0039

Chino, California, United States

Local Institution - 0012

La Palma, California, United States

Local Institution - 0043

Oceanside, California, United States

Local Institution - 0028

Stanford, California, United States

Envision Trials LLC

Bonita Springs, Florida, United States

Galiz Research

Hialeah, Florida, United States

Local Institution - 0030

Homestead, Florida, United States

New Access Research & Medical Services Inc - Kendall

Kendall, Florida, United States

Local Institution - 0032

Miami, Florida, United States

Banyan Behavioal Care Program - CSU

Miami, Florida, United States

Local Institution - 0007

Miami, Florida, United States

BioResearch Partner - Miami

Miami, Florida, United States

Medical Research of Central Florida

Orange City, Florida, United States

Local Institution - 0040

Orlando, Florida, United States

Local Institution - 0025

Atlanta, Georgia, United States

Local Institution - 0049

Austell, Georgia, United States

Local Institution - 0044

Marietta, Georgia, United States

Local Institution - 0046

Crystal Lake, Illinois, United States

Local Institution - 0048

Warrenville, Illinois, United States

Local Institution - 0014

Bloomfield Township, Michigan, United States

Local Institution - 0036

Detroit, Michigan, United States

Local Institution - 0034

Apple Valley, Minnesota, United States

Local Institution - 0041

Lincoln, Nebraska, United States

Local Institution - 0037

Buffalo, New York, United States

Local Institution - 0004

Monsey, New York, United States

Local Institution - 0038

Rochester, New York, United States

Local Institution - 0020

White Plains, New York, United States

Local Institution - 0042

Cary, North Carolina, United States

PPD Virtual - PPD - US

Wilmington, North Carolina, United States

Local Institution - 0031

Mason, Ohio, United States

The Rivus Wellness & Research Institute

Oklahoma City, Oklahoma, United States

Local Institution - 0052

Tulsa, Oklahoma, United States

Perelman School of Medicine at the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Local Institution - 0051

Cordova, Tennessee, United States

Psychiatric Consultants, Pc

Franklin, Tennessee, United States

Local Institution - 0016

Austin, Texas, United States

Local Institution - 0050

Dallas, Texas, United States

Local Institution - 0021

Fort Worth, Texas, United States

Local Institution - 0033

Houston, Texas, United States

Local Institution - 0026

Houston, Texas, United States

Local Institution - 0022

Houston, Texas, United States

Local Institution - 0010

Houston, Texas, United States

Pioneer Research Solutions, Inc.

Houston, Texas, United States

Local Institution - 0017

Irving, Texas, United States

Local Institution - 0013

McKinney, Texas, United States

Perceptive Pharma Research

Richmond, Texas, United States

Local Institution - 0035

San Antonio, Texas, United States

Local Institution - 0018

Stafford, Texas, United States

Local Institution - 0045

Petersburg, Virginia, United States

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NCT07379827

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