RecruitingPhase 1NCT04385082
Cannabis Effects as a Function of Sex
Sex-dependent Effects of Cannabis: Assessing Analgesic, Abuse-related and Pharmacokinetic Differences Between Men and Women
Sponsor
University of California, Los Angeles
Enrollment
160 participants
Start Date
Jul 8, 2021
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
Eligibility
Min Age: 21 YearsMax Age: 55 Years
Inclusion Criteria9
- Male or non-pregnant female aged 21-55 years
- Report use of cannabis an average of 1-7 days per week
- Not currently seeking treatment for their cannabis use
- Urine test positive for recent cannabis use for heavy users
- No reported adverse effects with cannabis smoking in light users
- Have a Body Mass Index from 18.5 - 34kg/m2.
- Able to perform all study procedures
- FEMALES: Currently practicing a non-hormonal effective form of birth control
- FEMALES: Must be regularly cycling
Exclusion Criteria7
- Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or cannabis use disorder
- Report using other illicit drugs in the prior 4 weeks
- History or current evidence of severe psychiatric illness or medical condition judged by the study physician and PI to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
- Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
- Current pain
- Insensitivity to the cold water stimulus of the Cold Pressor Test
- FEMALES: using a hormonal contraceptive
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGActive Cannabis
Smoked cannabis with THC
DRUGPlacebo Cannabis
Placebo smoked cannabis (no THC)
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04385082
Related Trials
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
NCT01719055118 locations
Testing the Pain Clinical Practice Guideline
NCT0585899611 locations
Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study
NCT075810802 locations
Clinical and Scientific Assessment of Pain and Painful Disorders
NCT027070291 location
Options for Pain Management Using Nonpharmacological Strategies
NCT055637921 location