Rheumatology Patient Registry and Biorepository

This is a patient registry and tissue collection study at Yale for people with rheumatic autoimmune diseases — conditions where the immune system mistakenly attacks the body's own tissues. Researchers will collect health information and optional tissue samples to better understand these diseases. **You may be eligible if...** - You are 18 or older - You have been diagnosed with a rheumatic autoimmune disease (such as lupus, rheumatoid arthritis, scleroderma, psoriatic arthritis, Sjögren's syndrome, or similar conditions) - You receive care at Yale Rheumatology clinics - Healthy volunteers aged 18+ with no autoimmune disease are also welcome **You may NOT be eligible if...** - You cannot give informed consent - You are allergic to lidocaine or epinephrine (if a skin biopsy is involved) - You have a history of poor wound healing (if a skin biopsy is involved) - Healthy volunteers: you must have a normal BMI and no chronic skin conditions Talk to your doctor to see if this trial is right for you.