Sjogren's Syndrome Clinical Trials

33 recruiting

Frequently Asked Questions

Common questions about Sjogren's Syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 36 trials

Recruiting

Characterization of Diseases With Salivary Gland Involvement

Healthy VolunteerSjogren's SyndromeSalivary Gland Disease
National Institute of Dental and Craniofacial Research (NIDCR)1,150 enrolled1 locationNCT02327884
Recruiting

The Pathogenesis and Natural History of Sjogren's Disease

Sjogren's SyndromeSalivary GlandPathogenesis
National Institute of Dental and Craniofacial Research (NIDCR)300 enrolled1 locationNCT01425892
Recruiting
Phase 1

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

Sjogren's SyndromeSjogren DiseaseSjögren
Cullinan Therapeutics Inc.36 enrolled10 locationsNCT07041099
Recruiting
Early Phase 1

Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases

Sjogren's SyndromeAutoimmune DiseasesIdiopathic Inflammatory Myopathies+3 more
Nanjing Bioheng Biotech Co., Ltd.20 enrolled1 locationNCT06548607
Recruiting
Phase 2

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

Sjogren's Syndrome
National Institute of Dental and Craniofacial Research (NIDCR)60 enrolled1 locationNCT07281456
Recruiting
Phase 1

An Exploratory Clinical Study of YTS109 Cell for R/R Autoimmune Diseases

Systemic Lupus ErythematosusLupus Nephritis (LN)Inflammatory Myopathy+3 more
China Immunotech (Beijing) Biotechnology Co., Ltd.18 enrolled1 locationNCT07236762
Recruiting
Phase 1

Exploratory Clinical Study on YTS109 Cell Therapy for Autoimmune Diseases

Systemic Lupus Erythematosus (SLE)Inflammatory MyopathyAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis+3 more
China Immunotech (Beijing) Biotechnology Co., Ltd.18 enrolled2 locationsNCT07236801
Recruiting

Rheumatology Patient Registry and Biorepository

Rheumatoid ArthritisLyme DiseaseSarcoidosis+17 more
Yale University5,000 enrolled1 locationNCT04402086
Recruiting
Phase 1

A Clinical Study of TI-0032-III Injection in Patients With Relapsed and Refractory Autoimmune Diseases

Systemic Lupus Erythematosus (SLE)Inflammatory MyopathySystemic Sclerosis (SSc)+2 more
Therorna12 enrolled1 locationNCT07413341
Recruiting
Phase 1

DR-0201 in Subjects With Autoimmune Diseases

SclerodermaSLEDermatomyositis+9 more
Dren Bio36 enrolled10 locationsNCT06647069
Recruiting
Not Applicable

Creating Health Course Study for People With Rheumatological Conditions

Rheumatoid ArthritisPsoriatic ArthritisSystemic Lupus Erythematosus+2 more
Terry L. Wahls200 enrolled1 locationNCT07180537
Recruiting

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Rheumatoid ArthritisSclerodermaSystemic Lupus Erythematosus+4 more
Duke University1,000 enrolled1 locationNCT03276923
Recruiting

Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases

Inflammatory Bowel DiseasesArthritis, RheumatoidSjogren's Syndrome+4 more
Centre Hospitalier Régional d'Orléans100 enrolled1 locationNCT06842316
Recruiting

Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis

Cardiovascular DiseasesOsteoporosisThrombosis+12 more
Guang'anmen Hospital of China Academy of Chinese Medical Sciences100 enrolled1 locationNCT07301892
Recruiting
Phase 1Phase 2

Analyse of Inflammatory Activity of Sjögren's Syndrome on 68Ga-FAPI PET-CT

Sjogren's Syndrome
Peking Union Medical College Hospital60 enrolled1 locationNCT07062523
Recruiting
Phase 1Phase 2

Chimeric Antigen Receptor Natural Killer Cell Therapy for High-risk Lymphoma Patients With Primary Sjogren's Syndrome

LymphomaPrimary Sjogren's Syndrome
Bangdong Gong6 enrolled1 locationNCT06967038
Recruiting

Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases

Rheumatoid ArthritisCeliac DiseaseSjogren's Syndrome+6 more
Santé Arménie French-Armenian Research Center800 enrolled6 locationsNCT05904301
Recruiting
Not Applicable

Wheat-free Diet in the Treatment of Sjogren's Syndrome

Sjogren's SyndromeNon-celiac Gluten Sensitivity
University of Palermo30 enrolled3 locationsNCT05644795
Recruiting

Assessment of Physician Consideration of EPRO's, from Patients with Gout, Rheumatoid Arthritis, Sjogren's Syndrome or Systemic Lupus, on the Frequency of Therapeutic Adjustments

Rheumatoid ArthritisSystemic Lupus ErythematosusGout+1 more
University Hospital, Strasbourg, France352 enrolled1 locationNCT05927688
Recruiting

Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome

Sjogren's SyndromeDry Eye Syndrome (DES)Xerophthalmia
Taipei Veterans General Hospital, Taiwan220 enrolled1 locationNCT06771427