Neuromodulation and Cognitive Training for Substance Use Disorders
University of Minnesota
80 participants
Jul 16, 2021
INTERVENTIONAL
Conditions
Summary
The relapsing nature of substance use disorder is a major obstacle to successful treatment. About 70% of those entering treatment will relapse within one year. To improve treatment outcome, new interventions targeting the underlying brain biomarkers of relapse vulnerability hold significant promise in reducing this critical public health problem. This study is testing a new intervention, namely tDCS-Augmented Cognitive Training, to engage these brain biomarkers to improve cognition and improve treatment outcomes.
Eligibility
Inclusion Criteria4
- Abstinent from any substance or alcohol use (excluding caffeine or nicotine) for a minimum of 3 weeks at study enrollment
- Has the intention to remain in their treatment program(s) until the end of the intervention portion of the study.
- Able to provide written consent and comply with study procedures.
- Meets the MINI 7 diagnostic criteria for either stimulant use disorder (SUD) or alcohol use disorder (AUD).
Exclusion Criteria8
- Any medical condition or treatment with neurological sequelae (i.e. stroke, tumor, HIV)
- Over 9 months of abstinence from substance use
- A head injury resulting in a loss of consciousness exceeding 30 minutes (i.e., moderate or severe TBI)
- Presence of a condition that would render study measures difficult or impossible to administer or interpret
- Age outside the range of 18 to 65
- Primary current substance use disorder diagnosis (according to MINI 7 diagnostic criteria) for a substance other than stimulant or alcohol, except for caffeine or nicotine (Nicotine use will be recorded but is not exclusionary)
- Entrance to the treatment program under a court mandate. (i.e. legally incarcerated)
- History of ECT or cortical energy exposure within the past 6 months, including participation in any other neuromodulation studies
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Interventions
We will apply tDCS in combination with cognitive training. All participants receive cognitive training, and will be randomized to receive either active or sham tDCS
cognitive training on computer
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04426214