Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer

This study is testing an immunotherapy drug called cemiplimab given before and after surgery for people with high-risk skin cancer (cutaneous squamous cell carcinoma, or cSCC) that has spread to nearby lymph nodes. **You may be eligible if...** - You have been diagnosed with high-risk cutaneous squamous cell carcinoma - Your cancer has spread to lymph nodes with involvement outside the lymph node capsule, or you have multiple large affected lymph nodes - You are able to have surgery - You are 18 or older **You may NOT be eligible if...** - Surgery is not an option for you due to other health problems - You are currently taking long-term immunosuppressant drugs (e.g., anti-rejection medication after an organ transplant) - You have had a prior organ transplant - You have had severe immune-related side effects from similar drugs in the past Talk to your doctor to see if this trial is right for you.