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RecruitingNot ApplicableNCT04432883

Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.

Targeted Transcranial Direct Current Stimulation to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia

Sponsor

University of New Mexico

Enrollment

50 participants

Start Date

Oct 18, 2022

Study Type

INTERVENTIONAL

Conditions

StrokeAphasia

Summary

62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.

Eligibility

Min Age: 25 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining a non-invasive brain stimulation technique (called tDCS) with speech therapy can improve language recovery in people who have had a stroke and are living with chronic aphasia (difficulty speaking or understanding language). **You may be eligible if...** - You are between 25 and 85 years old - You had a stroke more than 6 months ago - You have been diagnosed with aphasia (language difficulties after stroke) - You are right-handed (dominant for language) **You may NOT be eligible if...** - You have another neurological disease - You have significant mood disorder or substance abuse history in the past year - You have a metal implant or pacemaker in your head or neck - You have had brain damage on the right side Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive Comparator: Experimental: Active cathodal tDCS + language training

Cathodal tDCS raises neuronal membrane potentials, leading to decreased probability of depolarization from incoming stimuli. Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment.

BEHAVIORALSham Comparator: Placebo cathodal tDCS + Speech and language

Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment. .

Locations(1)

University of New Mexico Center for Brain Recovery and Repair

Albuquerque, New Mexico, United States

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NCT04432883

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