Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.
Targeted Transcranial Direct Current Stimulation to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia
University of New Mexico
50 participants
Oct 18, 2022
INTERVENTIONAL
Conditions
Summary
62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.
Eligibility
Inclusion Criteria5
- aged 25-85
- must be greater than 6 months post-stroke
- must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test, or during discourse production
- must be left-hemisphere dominant as demonstrated by aphasia onset subsequent to left hemisphere damage
- must be stimulable for naming
Exclusion Criteria7
- comorbid neurological disease.
- damage to the anterior right hemisphere.
- significant mood disorder.
- substance/alcohol dependence or abuse within the past year
- presence of any implanted electrical device or contraindications to tDCS or MRI
- recent medical instability (within 4 weeks)
- pregnancy
Interventions
Cathodal tDCS raises neuronal membrane potentials, leading to decreased probability of depolarization from incoming stimuli. Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment.
Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment. .
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04432883