RecruitingPhase 2NCT04434040

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

A Single Arm Phase 2 Trial of Atezolizumab With Sacituzumab Govitecan to Prevent Recurrence in Triple Negative Breast Cancer (ASPRIA)


Sponsor

Dana-Farber Cancer Institute

Enrollment

40 participants

Start Date

Jul 2, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine if a combination of two drugs sacituzumab govitecan and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulating tumor DNA in the blood. This research study involves the following investigational drugs: * Sacituzumab govitecan * Atezolizumab


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of two drugs — atezolizumab (immunotherapy) and sacituzumab govitecan (a targeted antibody-drug) — to prevent triple-negative breast cancer from coming back after surgery in patients who still had cancer remaining after neoadjuvant chemotherapy. **You may be eligible if...** - You have triple-negative breast cancer (a type that does not respond to hormone therapy or HER2-targeted therapy) - You completed chemotherapy before surgery, but cancer was still found in the breast or lymph nodes after surgery - You have not yet started additional (adjuvant) chemotherapy after surgery - You are 18 or older **You may NOT be eligible if...** - You have previously received sacituzumab govitecan, irinotecan, or similar antibody-drug treatments - You have active autoimmune disease - You are pregnant or breastfeeding - You have significant heart, liver, or lung disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtezolizumab

Atezolizumab is a type of antibody and is administered intravenously.

DRUGSacituzumab govitecan

Sacituzumab govitecan is an antibody drug conjugate and is administered intravenously


Locations(7)

University of California San Francisco

San Francisco, California, United States

University of Chicago Medical Center

Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital

New Lenox, Illinois, United States

University of Chicago Medical Center for Advanced Care Orland Park

Orland Park, Illinois, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

University of Pennsylvania-Abramson Cancer Center

Philadelphia, Pennsylvania, United States

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT04434040


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