RecruitingPhase 2NCT04440267

Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage

A Prospective, Single Arm, Open Label, Clinical Trial to Evaluate the Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage

Sponsor

Institute of Hematology & Blood Diseases Hospital, China

Enrollment

50 participants

Start Date

Jul 8, 2020

Study Type

INTERVENTIONAL

Conditions

Acute Leukemia of Ambiguous Lineage

Summary

In this prospective, single arm, open label, clinical trial, a total of 50 acute leukemia of ambiguous lineage patients will be enrolled. Patients will receive acute lymphoblastic leukemia (ALL) -based chemotherapy and are permitted to receive allogeneic hematopoietic stem cell transplantation (HSCT) after CR . Otherwise, they will finish the consolidation chemotherapy. Patients with t(9;22) will receive chemotherapy combined with tyrosine kinase inhibitors. The purpose of current study is to evaluate the clinical efficacy of ALL-based chemotherapy，effect of genetic abnormality and minimal residual disease (MRD) on prognosis in patients with acute leukemia of ambiguous lineage.

Eligibility

Min Age: 14 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether chemotherapy regimens typically used for acute lymphoblastic leukemia (ALL) can effectively treat a rare type of leukemia called acute leukemia of ambiguous lineage, which has features of both common leukemia types. **You may be eligible if...** - You are 14 years or older - You have been diagnosed with acute leukemia of ambiguous lineage - Your organ function (liver, kidneys, heart) is adequate enough to tolerate treatment - Your general health and activity level are sufficient (ECOG performance status 2 or better) **You may NOT be eligible if...** - You have a serious heart condition, including a known long QT interval on ECG - You have active uncontrolled infection - You are pregnant or breastfeeding - You have had prior treatment for this leukemia (except emergency stabilizing treatment) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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