RecruitingNCT04440761

Barts-MINOCA Registry

Barts Myocardial Infarction With Non-Obstructed Coronary Arteries (MINOCA) Registry


Sponsor

Queen Mary University of London

Enrollment

3,000 participants

Start Date

Jul 1, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

The last 15 years the introduction of primary angioplasty has radically improved outcomes for acute myocardial infarction (AMI). However, the system wide availability of prompt investigation has revealed an important group of patients where progress has stalled, the diagnosis is unclear and therapeutic approaches are uncertain. Myocardial infarction with non-obstructive coronary arteries (MINOCA) is found in 1 - 13% of all patients with a clinical diagnosis of AMI. These patients present a therapeutic predicament since coronary revascularization is not appropriate. Guidelines do not exist for their management - yet the condition is not benign - the 12-month prognosis, although better than obstructive coronary artery disease patients is still guarded with recent data suggesting many questions remain unanswered.


Eligibility

Min Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This study is building a registry of patients who have had a heart attack but whose coronary arteries — the arteries that supply blood to the heart — appear normal or near-normal on an angiogram. This condition is called MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries) and it affects approximately 5–10% of heart attack patients. Because the arteries look normal, MINOCA is often misunderstood and can be underdiagnosed or undertreated. The causes are different from typical heart attacks and can include artery spasm, tiny clots, or inflammation of the heart muscle. By collecting detailed clinical data, imaging, and blood test results from MINOCA patients over time, researchers hope to better understand the underlying causes and outcomes of this condition, leading to better diagnosis and treatment guidelines. You may be eligible if: - You are 16 years old or older - You have received a diagnosis of MINOCA (heart attack without clear obstructive coronary artery disease) - Your cause of elevated troponin (a heart injury marker) is unclear at initial assessment You may NOT be eligible if: - You are under 16 years old Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERObservation only

Observation only


Locations(1)

Barts Health NHS Trust

London, United Kingdom

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NCT04440761


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