RecruitingNot ApplicableNCT04441619

Mechanisms and Modulation of Pain Modulatory Capacity

Sponsor

University of Florida

Enrollment

180 participants

Start Date

Nov 30, 2020

Study Type

INTERVENTIONAL

Conditions

Musculoskeletal Pain

Summary

This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to determine if endogenous capacity to modulate pain can be trained to maximize their body's ability to manage pain, much as the way in which athletic performance can be trained.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria4

Asymptomatic people (ie no current pain conditions)
Participants with widespread muscle pain (WMP) aged 18 years of age and older
Participants with WMP must meet the ACR (2010) diagnostic criteria of multiple regions of muscle pain
The asymptomatic group will be free of current wrist/hand, elbow, or shoulder pain and chronic pain conditions (eg irritable bowel syndrome, FM)

Exclusion Criteria6

Participation in a conditioning program specific to the biceps in the past 6 months
Any report of wrist/hand, elbow, or shoulder pain in the last 3 months
Any chronic medical conditions that may affect pain perception (e.g., diabetes, high blood pressure), kidney dysfunction, muscle damage, or major psychiatric disorder
Use of any intervention (including but not limited to medication, massage, and stretching) for symptoms induced by pain training for the duration of the study
Positive result on pre-MRI metal screening or pregnancy test due to contraindication for the MRI environment.
Any participant with ferromagnetic metal in the head, neck, or abdominal cavity

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