Musculoskeletal Pain Clinical Trials

54 recruitingLast updated: June 18, 2026

There are 54 actively recruiting musculoskeletal pain clinical trials across 17 countries. Studies span Not Applicable. Top locations include Boston, Massachusetts, United States, Istanbul, Turkey (Türkiye), Cincinnati, Ohio, United States. Updated daily from ClinicalTrials.gov.


Musculoskeletal Pain Trials at a Glance

54 actively recruiting trials for musculoskeletal pain are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 42 trials, with the heaviest enrollment activity in Boston, Istanbul, and Cincinnati. Lead sponsors running musculoskeletal pain studies include Beijing Tiantan Hospital, Children's Hospital Medical Center, Cincinnati, and Massachusetts General Hospital.

Browse musculoskeletal pain trials by phase

Treatments under study

About Musculoskeletal Pain Clinical Trials

Looking for clinical trials for Musculoskeletal Pain? There are currently 33 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Musculoskeletal Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Musculoskeletal Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 54 trials

Recruiting
Not Applicable

Weighted Blanket Use for Adults With Chronic Pain

Musculoskeletal PainSleep DisturbanceChronic Pain+1 more
National University of Natural Medicine44 enrolled1 locationNCT07498491
Recruiting
Not Applicable

Video Intervention for Older Adults With Chronic Pain

Musculoskeletal PainChronic PainOlder Adults With Chronic Pain
Butler Hospital100 enrolled1 locationNCT07404618
Recruiting
Not Applicable

Equipping Patients Using Interventions for Pain and Depression

DepressionMusculoskeletal PainChronic Pain+1 more
Indiana University304 enrolled1 locationNCT06500780
Recruiting
Not Applicable

Supraspinal Processing of Sensory Aspects of Pain

Musculoskeletal PainFibromyalgiaFunctional Abdominal Pain Syndrome+2 more
Children's Hospital Medical Center, Cincinnati255 enrolled1 locationNCT05814497
Recruiting
Not Applicable

The PROACTIVE Study for Black Elders

Pain, ChronicMusculoskeletal PainChronic Pain+2 more
University of Florida120 enrolled1 locationNCT06512727
Recruiting

Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian

Lower Limb InjuryHealthyMusculoskeletal Pain+2 more
Universidad Católica San Antonio de Murcia300 enrolled1 locationNCT06685094
Recruiting
Not Applicable

The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System

Musculoskeletal PainChronic PainMusculoskeletal Pain Disorder
Brooke Army Medical Center608 enrolled5 locationsNCT06940986
Recruiting

Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine

Work StressSensitizationMusculoskeletal Pain+2 more
Bozok University159 enrolled1 locationNCT07554664
Recruiting

The BRIDGE Pain Study

Pectus excavatumMusculoskeletal PainChronic Pain+4 more
Children's Hospital Medical Center, Cincinnati600 enrolled1 locationNCT07602595
Recruiting
Not Applicable

Neural Mechanisms of Light Driven Analgesia

Musculoskeletal PainFibromyalgiaHealthy Controls Group - Age and Sex-matched
University of North Carolina, Chapel Hill60 enrolled1 locationNCT07245303
Recruiting
Not Applicable

Life-Style Medicine for Chronic Musculoskeletal Pain in Older People

Pain ManagementMusculoskeletal PainChronic Pain+1 more
Chinese University of Hong Kong268 enrolled1 locationNCT07194239
Recruiting
Not Applicable

AI-Assisted Camera-Based Progressive Muscle Relaxation for Office Workers

work-related musculoskeletal disordersMusculoskeletal PainStress, Physiological+1 more
Istanbul Medipol University Hospital60 enrolled1 locationNCT07571967
Recruiting
Not Applicable

Effectiveness of Communication-Focused Pain Neuroscience Education in Chronic Musculoskeletal Pain

Chronic Musculoskeletal Pain
University of Thessaly90 enrolled1 locationNCT07001449
Recruiting

Exercise, Pain Beliefs, and Activity Patterns in Musculoskeletal Pain

Activity LevelMusculoskeletal Pain - Acute and Subacute ConditionsExercise (EX)+1 more
Istinye University55 enrolled1 locationNCT07528807
Recruiting
Not Applicable

Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial

Musculoskeletal PainChronic PainFibromyalgia
G. d'Annunzio University44 enrolled2 locationsNCT07048366
Recruiting
Not Applicable

Pain Disengagement Training (Open Pilot)

Chronic Musculoskeletal Pain
Massachusetts General Hospital10 enrolled1 locationNCT06870162
Recruiting
Not Applicable

Virtual Reality (VR) Self-Hypnosis Software

Musculoskeletal PainNeuropathic PainNeuralgia
Icahn School of Medicine at Mount Sinai25 enrolled1 locationNCT06398847
Recruiting
Not Applicable

Neural Mobilization to Improve Chronic Musculoskeletal Pain in Older Adults

Chronic Musculoskeletal Pain
Aveiro University4 enrolled1 locationNCT07449819
Recruiting
Not Applicable

Phase 1 Pilot of a Pragmatic Trial of EAET for Veterans With Chronic Pain

Musculoskeletal Pain
University of California, Los Angeles84 enrolled1 locationNCT07218757
Recruiting

Association of High PainDETECT Scores With Pain Region and Diagnosis in Patients Attending a Musculoskeletal and Sports Medicine Clinic

Musculoskeletal PainNeuropathic Pain
Uskudar University150 enrolled1 locationNCT07356115