Musculoskeletal Pain Clinical Trials

25 recruiting

Musculoskeletal Pain Trials at a Glance

41 actively recruiting trials for musculoskeletal pain are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 31 trials, with the heaviest enrollment activity in Boston, Istanbul, and Cincinnati. Lead sponsors running musculoskeletal pain studies include University of Thessaly, Massachusetts General Hospital, and VA Office of Research and Development.

Browse musculoskeletal pain trials by phase

Treatments under study

About Musculoskeletal Pain Clinical Trials

Looking for clinical trials for Musculoskeletal Pain? There are currently 25 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Musculoskeletal Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Musculoskeletal Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 41 trials

Recruiting

Exercise, Pain Beliefs, and Activity Patterns in Musculoskeletal Pain

Activity LevelMusculoskeletal Pain - Acute and Subacute ConditionsExercise (EX)+1 more
Istinye University55 enrolled1 locationNCT07528807
Recruiting
Not Applicable

Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial

Musculoskeletal PainChronic PainFibromyalgia
G. d'Annunzio University44 enrolled2 locationsNCT07048366
Recruiting
Not Applicable

Pain Disengagement Training (Open Pilot)

Chronic Musculoskeletal Pain
Massachusetts General Hospital10 enrolled1 locationNCT06870162
Recruiting
Not Applicable

Virtual Reality (VR) Self-Hypnosis Software

Musculoskeletal PainNeuropathic PainNeuralgia
Icahn School of Medicine at Mount Sinai25 enrolled1 locationNCT06398847
Recruiting
Not Applicable

Neural Mobilization to Improve Chronic Musculoskeletal Pain in Older Adults

Chronic Musculoskeletal Pain
Aveiro University4 enrolled1 locationNCT07449819
Recruiting
Not Applicable

Phase 1 Pilot of a Pragmatic Trial of EAET for Veterans With Chronic Pain

Musculoskeletal Pain
University of California, Los Angeles84 enrolled1 locationNCT07218757
Recruiting

Association of High PainDETECT Scores With Pain Region and Diagnosis in Patients Attending a Musculoskeletal and Sports Medicine Clinic

Musculoskeletal PainNeuropathic Pain
Uskudar University150 enrolled1 locationNCT07356115
Recruiting
Not Applicable

Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

Musculoskeletal PainChronic Pain
Palo Alto Veterans Institute for Research274 enrolled1 locationNCT06704061
Recruiting
Not Applicable

Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients

PainOpioidPilot Study+1 more
Massachusetts General Hospital100 enrolled1 locationNCT07265557
Recruiting
Not Applicable

The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain

COPDChronic Musculoskeletal Pain
VA Office of Research and Development136 enrolled1 locationNCT05701982
Recruiting
Not Applicable

Mechanisms and Modulation of Pain Modulatory Capacity

Musculoskeletal Pain
University of Florida180 enrolled1 locationNCT04441619
Recruiting
Not Applicable

Neural Mechanisms of Light Driven Analgesia

Musculoskeletal PainFibromyalgiaHealthy Controls Group - Age and Sex-matched
University of North Carolina, Chapel Hill60 enrolled1 locationNCT07245303
Recruiting
Not Applicable

Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain

Musculoskeletal PainChronic Pain
Brigham and Women's Hospital10 enrolled1 locationNCT06632535
Recruiting
Not Applicable

Equipping Patients Using Interventions for Pain and Depression

DepressionMusculoskeletal PainChronic Pain+1 more
Indiana University304 enrolled1 locationNCT06500780
Recruiting

Exploring the Effects of Smartphone and Game Addiction on Activity, Sleep, Stress, and Pain in Youth

SleepFatigue SymptomInactivity, Physical+3 more
Istanbul University - Cerrahpasa193 enrolled2 locationsNCT06994104
Recruiting

Translation and Validation of the Upper and Lower Limbs, Pain, Autonomy and Quality of Life Scales in Albanian

Lower Limb InjuryHealthyMusculoskeletal Pain+2 more
Universidad Católica San Antonio de Murcia300 enrolled1 locationNCT06685094
Recruiting
Not Applicable

Improving Health for Older Adults With Pain Through Engagement

Musculoskeletal PainChronic Pain
Massachusetts General Hospital200 enrolled1 locationNCT06119698
Recruiting
Not Applicable

Stepped-Care Intervention of Music and Imagery to Assess Relief (SCIMITAR) Trial

VeteransChronic Musculoskeletal PainMusic Therapy
Henry M. Jackson Foundation for the Advancement of Military Medicine180 enrolled1 locationNCT07217821
Recruiting
Not Applicable

This Project is a Three-arm RCT Evaluating Two, Single-session Behavioral Interventions for Adults With Chronic Musculoskeletal Pain (CMP) -- 1) Brief Mindfulness-Oriented Recovery Enhancement (B-MORE) vs. Empowered Relief (ER) -- Relative to the Traditional 8-week Version of MORE.

Chronic Musculoskeletal Pain
Florida State University39 enrolled1 locationNCT07193095
Recruiting
Not Applicable

Group-Based Psychological Treatments Over Video Conference for Older Veterans With Chronic Pain

Chronic Musculoskeletal Pain
VA Office of Research and Development216 enrolled2 locationsNCT06004804